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Hoffa’s Fat Pad Abnormality in the Development of Knee Osteoarthritis

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Current Concepts in Medical Research and Practice

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1039))

Abstract

Over the past two decades, many hypotheses have been put forward to explain the cause of knee osteoarthritis. Scientific reports bring up the role of adipose tissue in the activation of the inflammatory mechanisms, which is a characteristic feature of osteoarthritis natural history. Adipose tissue produces and releases cytokines, interleukins, and growth factors by means of paracrine, endocrine, and autocrine mechanisms. Hoffa’s fat pad (infrapatellar adipose tissue) plays a viable role in the initiation and progression of osteoarthritis due to its role in the activation and release of pro-inflammatory mediators. The degenerative joint disease is considered an inflammatory process. Therefore, in this article we overview the importance of Hoffa’s fat pad in the development and progression of osteoarthritis.

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References

  • Andriacchi TP, Mundermann A (2006) A role of the ambulatory mechanics in the initiation and progress of knee osteoarthritis. Curr Opin Rheumatol 18:514–518

    Article  PubMed  Google Scholar 

  • Andriacchi TP, Mundermann A, Smith RL, Alexander EJ, Dyrby CO (2004) A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng 32:447–457

    Article  PubMed  Google Scholar 

  • Berenbaum F, Sellam J (2008) Obesity and osteoarthritis: what are the links? Joint Bone Spine 75:667–668

    Article  PubMed  Google Scholar 

  • Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB (2004) Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthr Cartil 12(8):627–635

    Article  PubMed  Google Scholar 

  • Bohnsack M, Meier F, Walter GF, Hurschler C, SchmolkeS WCJ, Rühmann O (2005) Distribution of substance-P nerves inside the infrapatellar fat pad and the adjacent synovial tissue: a neurohistological approach to anterior knee pain syndrome. Arch Orthop Trauma Surg 125:592–597

    Article  PubMed  Google Scholar 

  • Bohnsack M, Meier F, Hurschler C, Halcour A, Wilharm A, Ostemeier S, Rühmann O, Wirth CJ (2009) Influence of an infrapatellar fat edema on patellofemoral biomechanics and knee kinematics: a possible relation to the anterior knee pain syndrome. Arch Orthop Trauma Surg 129(8):1025–1030

    Article  PubMed  Google Scholar 

  • Brentano F, Schorr O, Ospelt C, Stanczyk J, Gay RE, Gay S, Kyburz D (2007) Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities. Arthritis Rheum 56(9):2829–2839

    Article  CAS  PubMed  Google Scholar 

  • Chaldakov GN, Stankulov IS, Hristova M, Ghenev PI (2003) Adipobiology of disease: adipokines and adipokine-targeted pharmacology. Curr Pharm Des 9:1023–1031

    Article  CAS  PubMed  Google Scholar 

  • Chen TH, Chen L, Hsiel MS, Chang CP, Chou DT, Tsai SH (2006) Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta 1762:711–718

    Article  CAS  PubMed  Google Scholar 

  • Chowdhury TT, Salter DM, Bader DL, Lee DA (2008) Signal transduction pathways involving p38 MAPK, JNK, NF kappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. Inflamm Res 57:306–313

    Article  CAS  PubMed  Google Scholar 

  • Cicuttini FM, Baker JR, Spector TD (1996) The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol 23:1221–1226

    CAS  PubMed  Google Scholar 

  • Coppack SW (2001) Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60(3):349–356

    Article  CAS  PubMed  Google Scholar 

  • Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X, Benelli C (2009) The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum 60:3374–3377

    Article  CAS  PubMed  Google Scholar 

  • Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Nettem P, Pottie P (2003) Evidence for a kay role of leptin in osteoarthritis. Arthritis Rheum 48(11):3118–3129

    Article  CAS  PubMed  Google Scholar 

  • Dye SF, Vaupel GL, Dye CC (1998) Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia. Am J sports Med 26:773–777

    Article  CAS  PubMed  Google Scholar 

  • Ehling A, Schäffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Schölmerich J, Neumann E, Müller-Ladner U (2006) The potential of adiponectin in driving arthritis. J Immunol 176:4468–4478

    Article  CAS  PubMed  Google Scholar 

  • Englund M, Paradowski PT, Lohmander LS (2004) Association of radiographic hand osteoarthritis with radiographic knee osteoarthritis after menisectomy. Arthritis Rheum 50(2):469–475

    Article  CAS  PubMed  Google Scholar 

  • Fain JN (2006) Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74:443–477

    Article  CAS  PubMed  Google Scholar 

  • Fantuzzi G (2005) Adipose tissue, adipokines and inflamation. J Allergy Clin Immunol 115:911–919

    Article  CAS  PubMed  Google Scholar 

  • Ghosh F, Smith M (2002) Osteoarthritis, genetic and molecular mechanisms. Biogerontology 3:85–88

    Article  CAS  PubMed  Google Scholar 

  • Goldring MB (2000a) Osteoartritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2(6):459–465

    Article  CAS  PubMed  Google Scholar 

  • Goldring MB (2000b) The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43(9):1916–1926

    Article  CAS  PubMed  Google Scholar 

  • Goldring MB, Berenbaum F (2004) The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 427(Suppl):S37–S46

    Article  Google Scholar 

  • Goldring MB, Goldring SR (2007) Osteoarthritis. J Cell Physiol 213(3):626–634

    Article  CAS  PubMed  Google Scholar 

  • Gomez R, Lago F, Gomez-Reino J, Dieguez C, Gualillo O (2009) Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. J Mol Endocrinol 43:11–18

    Article  CAS  PubMed  Google Scholar 

  • Gosset M, Berenbaum F, Levy A, Pigenet A, Thirion S, Saffar JL, Jacques C (2006) Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene. Arthritis Res Ther 8(4):R135

    Article  PubMed  PubMed Central  Google Scholar 

  • Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, Jacques C (2008) Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum 58(5):1399–1409

    Article  CAS  PubMed  Google Scholar 

  • Groble M, Hagen KB, Natvig B, Dahl FA, Kvien TK (2008) Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord 9:132

    Article  Google Scholar 

  • Guévremont M, Martel-Pelletier J, Massicotte F, Tardif G, Pelletier JP, Ranger P, Lajeunesse D, Reboul P (2003) Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage. J Bone Miner Res 18(6):1073–1081

    Article  PubMed  Google Scholar 

  • Guilak F, Fermor B, Keefe FJ, Kraus VB, Olson SA, Pisetsky DS, Setton LA, Weinberg JB (2004) The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res 423:17–26

    Article  Google Scholar 

  • Hang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432

    Article  Google Scholar 

  • Iliopoulos D, Malizos KN, Tsezou A (2007) Epigenetic regulation of lepton affect MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis 66:1616–1621

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kalichman L, Li L, Kobyliansky E (2009) Prevalence, pattern and determinants of radiographic hand osteoarthritis in Turkmen community-based sample. Rheumatol Int 29:1143–1149

    Article  PubMed  Google Scholar 

  • Kohn D, Deiler S, Rudert M (1995) Arteria blond supply of the infrepatellar fat pad. Anatomy and clinical consequences. Arch Orthop Trauma Surg 114:72–75

    Article  CAS  PubMed  Google Scholar 

  • Ku JH, Lee CK, Joo BS, An BM, Choi SH, Wang TH, Cho HL (2009) Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin Rheumatol 28(12):1431–1435

    Article  PubMed  Google Scholar 

  • Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, Gomez-Reino JJ, Gualillo O (2008) A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthr Cartil 16(9):1101–1109

    Article  CAS  PubMed  Google Scholar 

  • Lee JH, Ort T, Ma K, Picha K, Carton J, Marsters PA, Lohmander LS, Baribaud F, Song XY, Blake S (2009) Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro. Osteoarthr Cartil 17(5):613–620

    Article  CAS  PubMed  Google Scholar 

  • Lehner B, Koeck FX, Capellino S, Schubert TE, Hofbauer R, Straub RH (1985) Preponderance of sensory versus sympathetic nerve fibers and increased cellularity in the infrapatellar fat pad in anterior knee pain patients after primary arthroplasty. J Orthop Res 154:37–43

    Google Scholar 

  • Lowson JP, Steere AC (1985) Lyme arthritis: radiologic findings. Radiology 154:37–43

    Article  Google Scholar 

  • Macule F, Sastre S, Lasurt S, Sala P, Segur JM, Mallofre C (2005) Hoffa’s fat pad resection in total knee arthoplasty. Acta Orthop Belg 71:714–717

    PubMed  Google Scholar 

  • Magi M, Branca A, Bucca C, Langerami V (1991) Hoffa disease. Ital J Orthop Traumatol 17:211–216

    CAS  PubMed  Google Scholar 

  • Matarese G, Leiter EH, La Cava A (2007) Leptin in autoimmunity: many questions, some answers. Tissue Antigens 70(2):87–95

    Article  CAS  PubMed  Google Scholar 

  • McGlashan SR, Cluett EC, Jansen CG, Poole CA (2008) Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters. Dev Dyn 237(8):2013–2020

    Article  CAS  PubMed  Google Scholar 

  • O’Shaughnessy MC, Carleson J, Haigh R, Kidd BL, Winyard PG (2006) The effect of substance P on nitric oxide relese in rheumatoid arthritis model. Inflamm Res 55:236–240

    Article  PubMed  Google Scholar 

  • Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM (1999) Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 10:161–166

    Article  CAS  PubMed  Google Scholar 

  • Otero M, Gomez Reino JJ, Gualillo O (2003) Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum 48:404–409

    Article  CAS  PubMed  Google Scholar 

  • Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, Mainard D, Netter P, Terlain B (2006) Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage 14(7):690–695

    Article  CAS  PubMed  Google Scholar 

  • Reid IR (2008) Relationships between fat and bone. Osteoporos Int 19:595–606

    Article  CAS  PubMed  Google Scholar 

  • Sanchez C, Deberg MA, Piccardi N, Msika P, Register JY, Henrotin YE (2005a) Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1 beta and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage 13(11):979–987

    Article  CAS  PubMed  Google Scholar 

  • Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE (2005b) Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthr Cartil 13(11):988–997

    Article  CAS  PubMed  Google Scholar 

  • Schäffler A, Ehling A, Neumann E, Herfarth H, Tarner I, Schölmerich J, Müller-Ladner U, Gay S (2003) Adipocytokines in synovial fluid. JAMA 290(13):1709–1710

    Article  PubMed  Google Scholar 

  • Shine B, Bourne JT, Begum Baig F, Dacre J, Doyle DV (1991) C-reactive protein and immunoglobulin G in synovial fluid and serum in joint disease. Ann Rheum Dis 50:32–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, Tsezou A (2007) Differential expression of leptin and leptin’s receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthr Cartil 15(8):872–883

    Article  CAS  PubMed  Google Scholar 

  • Spector TD, MacGregor AJ (2004) Risk factors for osteoarthritis: genetics. Osteoarthr Cartil 12 Suppl A:S39-44

    Google Scholar 

  • Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM (2007) Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 179(8):5483–5492

    Article  CAS  PubMed  Google Scholar 

  • Toda Y, Toda T, Takemura S, Wada T, Morimoto T, Ogawa R (1998) Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program. J Rheumatol 25:2181-2186

    Google Scholar 

  • Toussirot E, Streit G, Wendling D (2007) The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem 14:1095–1100

    Article  CAS  PubMed  Google Scholar 

  • Ushiyama T, Chanao T, Inoue K, Matsusue Y (2003) Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids. Ann Rheum Dis 62:108–112

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • van Lent PL, Blom AB, van der Kraan P, Holthuysen AE, Vitters E, van Rooijen N, Smeets RL, Nabbe KC, van den Berg WB (2004) Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. Arthritis Rheum 50(1):103–111

    Article  PubMed  Google Scholar 

  • Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, Päivärinta U, Moilanen T, Moilanen E (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage – mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm 2009:345838. doi:10.1155/2009/345838

    Article  PubMed  PubMed Central  Google Scholar 

  • Wallis WJ, Simkin PA, Nelp WB (1987) Protein traffic in human synovial fluids. Ann Rheum Dis 30:57–63

    CAS  Google Scholar 

  • Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Schölmerich J, Straub RH (2005) Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis 64(1):13–20

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Witowski D, Wagrowska-Danilewicz M (1999) Distrybution of substance P nerve fibers in the knee joint in patients with anterior knee pain syndrome. A preliminary report. Knee Surg Sport Traumatol Arthrosc 7:177–183

    Article  Google Scholar 

  • Yusuf E, Nelissen RG, Ioan-Facsinay A, Stojanovic-Susulic V, DeGroot J, van Osch G, Middeldorp S, Huizinga TW, Kloppenburg M (2010) Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann Rheum Dis 69(4):761–765

    Article  PubMed  Google Scholar 

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The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Neurotraumatology and Traumatology, Children’s University Hospital, Warsaw Medical University, 63A Żwirki i Wigury Street, 02-091, Warsaw, Poland

    Wojciech Paduszyński, Mateusz Jeśkiewicz, Paweł Uchański & Sebastian Gackowski

  2. Department of Immunopathology of Infectious and Parasitic Diseases, Warsaw Medical University, 3C Pawinskiego Street, 02-106, Warsaw, Poland

    Marek Radkowski

  3. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, 63A Żwirki i Wigury Street, 02-091, Warsaw, Poland

    Urszula Demkow

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  1. Wojciech Paduszyński
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  2. Mateusz Jeśkiewicz
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  3. Paweł Uchański
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  4. Sebastian Gackowski
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  5. Marek Radkowski
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  6. Urszula Demkow
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Correspondence to Urszula Demkow .

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  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Paduszyński, W., Jeśkiewicz, M., Uchański, P., Gackowski, S., Radkowski, M., Demkow, U. (2017). Hoffa’s Fat Pad Abnormality in the Development of Knee Osteoarthritis. In: Pokorski, M. (eds) Current Concepts in Medical Research and Practice. Advances in Experimental Medicine and Biology(), vol 1039. Springer, Cham. https://doi.org/10.1007/5584_2017_77

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