Abstract
The aim of the present study was to quantify the effects of treatment of children with Henoch-Schönlein nephritis (HSN) evaluated on the basis of kidney biopsy findings. Data were analyzed from 32 patients with HSN (mean age 9.3 ± 3.5 years, 19 with nephrotic syndrome/nephrotic proteinuria NS/NP, 13 with nephritic syndrome NphS), in whom the diagnosis was confirmed by kidney biopsy. Patients received immunosuppressive treatment (azathioprine or cyclophosphamide) and/or steroids and renoprotection according to a defined protocol. Patients were referred to a specific treatment protocol selected on the basis of clinical symptoms of nephropathy (NS/NP or NphS) and histopathological grade according to the WHO classification. Grade I–II changes were defined as mild HSN, and grade III–V WHO as severe HSN. The follow-up kidney biopsy was performed upon obtaining parental consent in 17 children. Following treatment, proteinuria resolved in 78 % children with mild HSN and 87 % children with severe HSN. In kidney biopsy, histological improvement was seen in 59 % children and no worsening in 35 %. We conclude that a flexible treatment protocol related to clinical symptoms and histological staging may contribute to a reduction of proteinuria and a delay in disease progression in children with HSN.
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Mizerska-Wasiak, M., Małdyk, J., Demkow, U., Roszkowska-Blaim, M., Pańczyk-Tomaszewska, M. (2016). Treatment Outcomes in Children with Henoch-Schönlein Nephritis. In: Pokorski, M. (eds) Prospect in Pediatric Diseases Medicine. Advances in Experimental Medicine and Biology(), vol 912. Springer, Cham. https://doi.org/10.1007/5584_2016_231
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DOI: https://doi.org/10.1007/5584_2016_231
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