Fluorotelomer Alcohols’ Toxicology Correlates with Oxidative Stress and Metabolism

Yang, Yujuan; Meng, Kuiyu; Chen, Min; Xie, Shuyu; Chen, Dongmei

doi:10.1007/398_2020_57

Yujuan Yang⁸,
Kuiyu Meng⁸,
Min Chen⁸,
Shuyu Xie⁸ &
…
Dongmei Chen^8,9

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 256))

923 Accesses
2 Citations

Abstract

Fluorotelomer alcohols (FTOHs) are widely used as industrial raw materials due to their unique hydrophobic and oleophobic properties. However, because of accidental exposure to products containing FTOHs or with the widespread use of FTOHs, they tend to contaminate the water and the soil. There are reports demonstrating that FTOHs can cause various harmful effects in animals and humans (for example, neurotoxicity, hepatotoxicity, nephrotoxicity, immunotoxicity, endocrine-disrupting activity, and developmental and reproductive toxicities). Oxidative stress is related to a variety of toxic effects induced by FTOHs. To date, few reviews have addressed the relationship between the toxicity of FTOHs and oxidative stress. This article summarises research demonstrating that the toxicity induced by FTOHs correlates with oxidative stress and metabolism. Furthermore, during the metabolic process of FTOHs, a number of cytochrome P450 enzymes (CYP450) are involved and many metabolites are produced by these enzymes, which can induce oxidative stress. This is also reviewed.

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Abbreviations

4-3 FTCA:: 4-3 Fluorotelomer carboxylic acid
5-3 FTCA:: 5-3 Fluorotelomer carboxylic acid
6-2 FTAL:: 6-2 Fluorotelomer aldehyde
6-2 FTCA:: 6-2 Saturated fluorotelomer carboxylic acids
6-2 FTUCA:: 6-2 Unsaturated fluorotelomer carboxylic acids
7-2 sFTOH:: 7-2 Secondary fluorotelomer alcohol
7-3 AL:: 7-3 Aldehyde
7-3 FTCA:: 7-3 Acid
7-3 TA:: 7-3 Acid taurine
7-3 UAL:: 7-3 α-β Unsaturated aldehyde
7-3UA:: 7-3 Unsaturated acid
8-2 FTAL:: 8-2 Fluorotelomer aldehyde
8-2 FTCA:: 8-2 Fluorotelomer acid
8-2 FTOH-Sulf:: 8-2 Fluorotelomer alcohol sulphate
8-2 FTUAL:: 8-2 Fluorotelomer α, β-unsaturated aldehyde
8-2 FTUCA:: 8-2 Fluorotelomer unsaturated acid
8-2 uFTOH-GS:: 8-2 Unsaturated alcohol conjugate
8-OH-dG:: 8-Hydroxydeoxyguanosine
CAT:: Catalase
CYP450:: Cytochrome P450 enzymes
EC50:: Concentration causing 50% cell death
FCSs:: Food contact substances
FTOHs:: Fluorotelomer alcohols
GP_X:: Glutathione peroxidase
GR:: Glutathione reductase
GSH:: Glutathione
GST:: Glutathione S-transferase
H₂O₂:: Hydrogen peroxide
hER:: Human estrogen receptor
LC50:: Median lethal concentration
LD50:: Median lethal dose
MDA:: Malondialdehyde
NOAEL:: No-observed-adverse-effect level
O₂⁻:: Superoxide anion radical
PFASs:: Polyfluoroalkyl substances
PFBA:: Perfluorobutanoic acid
PFCAs:: Perfluoroalkyl carboxylic acids
PFCs:: Poly- and perfluorinated compounds
PFHpA:: Perfluoroheptanoic acid
PFHxA:: Perfluorohexanoic acid
PFNA:: Perfluorononanoic acid
PFOA:: Perfluorooctanoic acid
PFOS:: Perfluorooctanesulfonic acid
PFOSA:: Perfluorooctanesulfonamide
PFPeA:: Perfluoropentanoic acid
ROS:: Reactive oxygen species
SOD:: Superoxide dismutase

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Acknowledgments

This work was supported by Natural Science Foundation of China (NSFC, 31572570) and Risk Assessment of Unknown and known hazard factors of livestock and poultry products (GJFP2019007).

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National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei, China
Yujuan Yang, Kuiyu Meng, Min Chen, Shuyu Xie & Dongmei Chen
MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China
Dongmei Chen

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Yujuan Yang
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Min Chen
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Shuyu Xie
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Pim de Voogt

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Yang, Y., Meng, K., Chen, M., Xie, S., Chen, D. (2020). Fluorotelomer Alcohols’ Toxicology Correlates with Oxidative Stress and Metabolism. In: de Voogt, P. (eds) Reviews of Environmental Contamination and Toxicology Volume 256. Reviews of Environmental Contamination and Toxicology, vol 256. Springer, Cham. https://doi.org/10.1007/398_2020_57

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DOI: https://doi.org/10.1007/398_2020_57
Published: 19 April 2021
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