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Catalysis: Unlimited Frontiers – Our Early Personal Journey into the World of Palladium

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Inventing Reactions

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 44))

Abstract

Stimulated by our collaboration in the chemistry of insects, the absence of direct ways to replace allylic C–H bonds by C–C bonds led us to teach ourselves about the organic chemistry of palladium. This journey evolved beyond allylic alkylation and led to the semi-rational development of alkene–alkyne coupling and discovery of palladium complexes of trimethylenemethane as reactive intermediates for cycloadditions to five, seven, and nine membered carbo- and heterocycles. These new synthetic tools enabled facile strategies to complex structures possessing interesting properties, notably of biological relevance.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Stanford University, Stanford, CA, 94305-5080, USA

    Barry M. Trost

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  1. Barry M. Trost
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Correspondence to Barry M. Trost .

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Editors and Affiliations

  1. , FB Chemie - Organische Chemie, TU Kaiserslautern, Erwin-Schrödinger-Str. 54, Kaiserslautern, 67663, Germany

    Lukas J. Gooßen

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Trost, B.M. (2012). Catalysis: Unlimited Frontiers – Our Early Personal Journey into the World of Palladium. In: Gooßen, L. (eds) Inventing Reactions. Topics in Organometallic Chemistry, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_2012_50

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