Dirk Gründemann, Edgar Schömig
Department of Pharmacology, University of Cologne, Cologne, Germany
dirk.gruendemann@uni-koeln.de,
edgar.schoemig@medizin.uni-koeln.de
Synonyms
Non-neuronal monoamine transporters
Definition
Cellular membranes are virtually impenetrable to charged organic compounds, so dedicated integral membrane proteins must be present to allow passage of a variety of endogenous organic compounds and drugs. Transport of organic cations across cellular membranes was first identified in the kidney. The proximal tubule efficiently clears model compounds like TEA and N1-methylnicotinamide (see Fig. 1) from the blood by trans-epithelial secretion into urine. Secretion of organic cations is thought to serve in the elimination or detoxification of metabolites and xenobiotics (such as many drugs positively charged at physiological pH). The term “organic cation transporters” (OCT) originally refers to two distinct mechanisms identified and characterized by radiotracer...
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References
Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549–552
Gründemann D, Schechinger B, Rappold GA, Schömig E (1998) Molecular identification of the corticosterone-sensitive extraneuronal monoamine transporter. Nature Neurosci. 1:349–351
Sweet DH, Pritchard JB (1999) The molecular biology of renal organic anion and organic cation transporters. Cell Biochem. Biophys. 31:89–118
Koepsell H (1998) Organic cation transporters in intestine, kidney, liver, and brain. In: Hoffmann JF (ed) Annu. Rev. Physiol. Annual Reviews, Palo Alto, California, p243–266
Gründemann D, Liebich G, Kiefer N, Köster S, Schömig E (1999) Selective substrates for non-neuronal monoamine transporters. Mol. Pharmacol. 56:1–10
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© 2004 Springer-Verlag
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(2004). Organic Cation Transporters. In: Encyclopedic Reference of Molecular Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29832-0_1180
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DOI: https://doi.org/10.1007/3-540-29832-0_1180
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-42843-5
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