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Synonyms

Transposon is a short and most commonly used term for transposable element. Transposons are also referred to as mobile genetic elements, which is a wide category including the classical transposable elements, integrating viruses, mobile introns and some other products of DNA recombination. Transposons are also called “jumping genes”, for their ability to move.

Definition

Transposons are discrete segments of DNA that have the distinctive ability to move and replicate within genomes. Transposons were discovered in the 1940's by Barbara McClintock (who later was awarded with the Nobel Prize for this discovery) in the maize genome and have since been found ubiquitously in essentially all living organisms. The process of element movement is generally called transposition and can contribute to insertional mutagenesis, altered gene expression and recombination. Transposons make up significant fractions of genomes; for example, about 45% of the human genome is composed of sequences of...

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References

  1. International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409:860-921

    Google Scholar 

  2. Moran JV, Gilbert N (2002) Mammalian LINE‐1 retrotransposons and related elements. In: Craig NL, Craigie R, Gellert M et al (eds) Mobile DNA II. ASM Press, Washington pp 836–869

    Google Scholar 

  3. Hartl DL, Lozovskaya ER, Nurminsky DI et al (1997) What restricts the activity of mariner‐like transposable elements? Trends Genet 13:197–201

    Article  PubMed  CAS  Google Scholar 

  4. Ivics Z, Hackett PB, Plasterk RH et al (1997) Molecular reconstruction of Sleeping Beauty, a Tc1‐like transposon from fish, and its transposition in human cells. Cell 91:501–510

    Article  PubMed  CAS  Google Scholar 

  5. Miskey CS, Izsvak ZS, Plasterk RH, Ivics Z (2003) The Frog Prince: a reconstructed transposon from Rana pipiens with high activity in vertebrates. Nucleic Acids Res 31:6873–6881

    Article  PubMed  CAS  Google Scholar 

  6. Kazazian HH Jr (1999) An estimated frequency of endogenous insertional mutations in humans. Nat Genet 22:130

    Article  PubMed  CAS  Google Scholar 

  7. Deininger PL, Batzer MA (1999) Alu repeats and human disease. Mol Genet Metab 67:183–193

    Article  PubMed  CAS  Google Scholar 

  8. Fedoroff N (2002) Control of mobile DNA. In: Craig NL, Craigie R, Gellert M (eds) et al Mobile DNA II. ASM Press, Washington, pp 836–869

    Google Scholar 

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Correspondence to Zoltán Ivics .

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© 2005 Springer-Verlag

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Ivics, Z., Walisko, O., Izsvák, Z. (2005). Transposons. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_1860

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