Abstract
Nuclear Medicine is a priori an entity that provides images with a molecular basis. The current PET imaging with the workhorse agent 18F-FDG quantifies glucose metabolism; the upcoming agent 18F-FLT enables imaging of cellular proliferation (Larson 2009). Furthermore, there are radiolabeled antibodies and peptides in clinical use and even more in clinical trials. Together, these help define classical molecular imaging with targeted (e.g. antibodies, MIBG) imaging agents. Not surprisingly, PET imaging is advertized in the community as molecular imaging and has been labeled as such for quite some time. However, while Nuclear Medicine is certainly one of the driving forces to further clinical molecular imaging there are other modalities that contribute to the field of molecular imaging today and they should not be underestimated (Weissleder and Mahmood 2001; Weissleder 2006). These add alternative perspectives to this growing discipline in addition to their increasing importance of multimodality imaging, which may bring new modalities into the realm of Nuclear Medicine in the future. This trend has already begun with the advent of MRI/PET (Schlemmer 2008), the future may see even more novel combinations, for example with optical imaging modalities (Kirsch 2007) or optical imaging of radiotracers through Cerenkov imaging (Ruggiero 2010). This chapter will make the reader more familiar with molecular imaging agents beyond PET.
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Grimm, J. (2012). Developing Probes for Molecular Imaging. In: Baum, R. (eds) Therapeutic Nuclear Medicine. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_716
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