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Nutritional Interventions to Prevent the Development of Atopic Diseases: A Focus on Cow’s Milk Allergy

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Allergic Diseases – From Basic Mechanisms to Comprehensive Management and Prevention

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 268))

Abstract

In the western world the prevalence of atopic diseases such as food allergies is increasing highly significantly. One of the earliest and most prevalent food allergies occurring in the first year of life is cow’s milk allergy. No treatment is available and only avoidance of the cow’s milk allergens prevents the occurrence of an allergic reaction. Since cow’s milk allergic children have an increased risk of developing other allergies later in life, investigating nutritional strategies to prevent the development of cow’s milk allergy by developing oral tolerance is of high interest. Nutritional components such as prebiotics, probiotics, synbiotics and long-chain polyunsaturated fatty acids possess potential to support the maturation of the immune system early in life that might prevent the development of cow’s milk allergy. The available research, so far, shows promising results particularly on the development of eczema. However, the preventive effects of the nutritional interventions on the development of food allergy are inconclusive. Future research may benefit from the combination of various dietary components. To clarify the preventive effects of the nutritional components in food allergy more randomized clinical trials are needed.

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Authors and Affiliations

  1. Division of Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of science, Utrecht University, Utrecht, The Netherlands

    Kirsten Szklany, Aletta D. Kraneveld, Machteld M. Tiemessen, Johan Garssen & Leon M. J. Knippels

  2. Veterinary Pharmacology and Therapeutics, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands

    Aletta D. Kraneveld

  3. Department of Immunology, Danone Nutricia Research, Utrecht, The Netherlands

    Machteld M. Tiemessen, Johan Garssen & Leon M. J. Knippels

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  1. Kirsten Szklany
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  2. Aletta D. Kraneveld
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  3. Machteld M. Tiemessen
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  4. Johan Garssen
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  5. Leon M. J. Knippels
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Correspondence to Leon M. J. Knippels .

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Editors and Affiliations

  1. Department of Environmental Medicine, University Augsburg, Medical Faculty, Augsburg, Germany

    Claudia Traidl-Hoffmann

  2. Charité - Universitätsmedizin Berlin, Klinik für Dermatologie, Berlin, Berlin, Germany

    Torsten Zuberbier

  3. Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hanover, Germany

    Thomas Werfel

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Szklany, K., Kraneveld, A.D., Tiemessen, M.M., Garssen, J., Knippels, L.M.J. (2021). Nutritional Interventions to Prevent the Development of Atopic Diseases: A Focus on Cow’s Milk Allergy. In: Traidl-Hoffmann, C., Zuberbier, T., Werfel, T. (eds) Allergic Diseases – From Basic Mechanisms to Comprehensive Management and Prevention . Handbook of Experimental Pharmacology, vol 268. Springer, Cham. https://doi.org/10.1007/164_2021_480

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