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The Cells of Bone and Their Interactions

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Bone Regulators and Osteoporosis Therapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 262))

Abstract

Bone tissue is comprised of a collagen-rich matrix containing non-collagenous organic compounds, strengthened by mineral crystals. Bone strength reflects the amount and structure of bone, as well as its quality. These qualities are determined and maintained by osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells) on the surface of the bone and osteocytes embedded within the bone matrix. Bone development and growth also involves cartilage cells (chondrocytes). These cells do not act in isolation, but function in a coordinated manner, including co-ordination within each lineage, between the cells of bone, and between these cells and other cell types within the bone microenvironment. This chapter will briefly outline the cells of bone, their major functions, and some communication pathways responsible for controlling bone development and remodeling.

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Authors and Affiliations

  1. Bone Biology and Disease Unit, St. Vincent’s Institute of Medical Research, Melbourne, VIC, Australia

    Natalie A. Sims

  2. Department of Medicine, The University of Melbourne, St. Vincent’s Hospital, Melbourne, VIC, Australia

    Natalie A. Sims

  3. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia

    Niloufar Ansari

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  1. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Paula H. Stern

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Ansari, N., Sims, N.A. (2019). The Cells of Bone and Their Interactions. In: Stern, P.H. (eds) Bone Regulators and Osteoporosis Therapy. Handbook of Experimental Pharmacology, vol 262. Springer, Cham. https://doi.org/10.1007/164_2019_343

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