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NOP Receptor Signaling Cascades

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The Nociceptin/Orphanin FQ Peptide Receptor

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 254))

Abstract

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a G protein-coupled receptor with wide distribution throughout the peripheral and central nervous system. Similar to other opioid receptors, NOP receptors couple to intracellular second messengers and regulatory proteins to affect biological systems. In this chapter, we review the current literature for NOP signaling cascades including their role as classic GPCRs, the investigation of their kinase and arrestin signaling pathways, and the importance of examining biased signaling to critically evaluate the therapeutic potential of novel NOP agonists.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA

    Kyle E. Parker

  2. Department of Anesthesiology and Pain Medicine, Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA

    Michael R. Bruchas

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  1. Kyle E. Parker
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  2. Michael R. Bruchas
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Correspondence to Michael R. Bruchas .

Editor information

Editors and Affiliations

  1. Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, NC, USA

    Mei-Chuan Ko

  2. Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy

    Girolamo Caló

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Parker, K.E., Bruchas, M.R. (2019). NOP Receptor Signaling Cascades. In: Ko, MC., Caló, G. (eds) The Nociceptin/Orphanin FQ Peptide Receptor. Handbook of Experimental Pharmacology, vol 254. Springer, Cham. https://doi.org/10.1007/164_2019_215

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