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Pathways of CGRP Release from Primary Sensory Neurons

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Calcitonin Gene-Related Peptide (CGRP) Mechanisms

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 255))

Abstract

The benefit reported in a variety of clinical trials by a series of small molecule antagonists for the calcitonin gene-related peptide (CGRP) receptor, or four monoclonal antibodies against the neuropeptide or its receptor, has underscored the release of CGRP from terminals of primary sensory neurons, including trigeminal neurons, as one of the major mechanisms of migraine headaches. A large variety of excitatory ion channels and receptors have been reported to elicit CGRP release, thus proposing these agonists as migraine-provoking agents. On the other side, activators of inhibitory channels and receptors may be regarded as potential antimigraine agents. The knowledge of the intracellular pathways underlying the exocytotic process that results in CGRP secretion or its inhibition is, therefore, of importance for understanding how migraine pain originates and how to treat the disease.

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Acknowledgments

We thank the Migraine Research Foundation, New York (Grant 2017), and Ministero dell’Istruzione, dell’Università e della Ricerca (MiUR), Rome (PRIN 201532AHAE_003).

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Authors and Affiliations

  1. Department of Health Sciences, Section of Clinical Pharmacology and Oncology, Headache Center, University of Florence, Florence, Italy

    Francesco De Logu, Romina Nassini, Lorenzo Landini & Pierangelo Geppetti

Authors
  1. Francesco De Logu
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  2. Romina Nassini
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  3. Lorenzo Landini
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  4. Pierangelo Geppetti
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Corresponding author

Correspondence to Pierangelo Geppetti .

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Editors and Affiliations

  1. School of Cardiovascular Medicine & Sciences, King’s College London, London, UK

    Susan D. Brain

  2. Department of Health Sciences, University of Florence, Florence, Italy

    Pierangelo Geppetti

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De Logu, F., Nassini, R., Landini, L., Geppetti, P. (2018). Pathways of CGRP Release from Primary Sensory Neurons. In: Brain, S., Geppetti, P. (eds) Calcitonin Gene-Related Peptide (CGRP) Mechanisms. Handbook of Experimental Pharmacology, vol 255. Springer, Cham. https://doi.org/10.1007/164_2018_145

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