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Sex-Related Differences in GI Disorders

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Gastrointestinal Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 239))

Abstract

Epidemiological studies indicate sex-related differences among functional gastrointestinal disorders (FGIDs) wherein females are more likely to receive a diagnosis than their male counterparts. However, the mechanism by which females exhibit an increased vulnerability for development of these pathophysiologies remains largely unknown, and therapeutic treatments are limited. The current chapter focuses on clinical research outlining our current knowledge of factors that contribute to the female predominance among FGID patients such as the menstrual cycle and sex hormones. In addition, we will discuss progress in preclinical research, including animal models, which serve as valuable tools for the investigation of the development and long term manifestation of symptoms observed within the patient population. Although much progress has been made, additional longitudinal studies in both clinical and preclinical research are necessary to identify more specific mechanisms underlying sex-related differences in FGIDs as well as targets for improved therapeutic approaches.

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Authors and Affiliations

  1. Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA

    Dawn K. Prusator

  2. G. Oppenheimer Center for Neurobiology of Stress and Resilience, 10833 Le Conte Avenue, CHS 42-210, Los Angeles, CA, 90095-7378, USA

    Lin Chang

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  1. Dawn K. Prusator
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Correspondence to Lin Chang .

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  1. Health Sciences Center, The University of Oklahoma, Oklahoma City, Oklahoma, USA

    Beverley Greenwood-Van Meerveld

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Prusator, D.K., Chang, L. (2017). Sex-Related Differences in GI Disorders. In: Greenwood-Van Meerveld, B. (eds) Gastrointestinal Pharmacology . Handbook of Experimental Pharmacology, vol 239. Springer, Cham. https://doi.org/10.1007/164_2016_121

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