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Bacterial Biofilms on Wounds, a Major Factor That Delays Wound Healing and a Potential Threat to Human Life and Economy

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Biofilm, Pilonidal Cysts and Sinuses

Part of the book series: Recent Clinical Techniques, Results, and Research in Wounds ((RCTRRW,volume 1))

Abstract

Biofilms are responsible for over 80% of hospital- and community-acquired infections and are highly prevalent, costly to treat, and a significant cause of morbidity and mortality. Microbiological analysis of wound infection revealed existence of polymicrobial including multiple species of bacteria (both aerobic and anaerobic), fungi, and viruses but bacteria are the principal pathogens and are responsible for early dominance, biofilm formation, and infection on wounds. For instance, reports suggest that over 50% of diabetic foot ulcerations lead to infection, and consequently lower extremity amputation. However, 85% of diabetes-related amputations are preventable if infection is treated early. Bacterial resistance to antimicrobial agents is a major factor that influences apprehends of wound healing and a potential threat to human life and economy. With the increase in bacterial resistance to antibiotics and wound regime novel strategies are essential to encounter biofilms and its associated infections.

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Authors and Affiliations

  1. Department of Infectious Diseases and Immunology, Sydney Medical School, The University of Sydney Charles Perkins Centre, Camperdown, NSW, 2006, Australia

    Theerthankar Das Ph.D., Onder Kimyon & Michael J. Manefield

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  1. Theerthankar Das Ph.D.
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  2. Onder Kimyon
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  3. Michael J. Manefield
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Correspondence to Theerthankar Das Ph.D. .

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    Melvin A. Shiffman

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    Mervin Low

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Das, T., Kimyon, O., Manefield, M.J. (2017). Bacterial Biofilms on Wounds, a Major Factor That Delays Wound Healing and a Potential Threat to Human Life and Economy. In: Shiffman, M., Low, M. (eds) Biofilm, Pilonidal Cysts and Sinuses. Recent Clinical Techniques, Results, and Research in Wounds, vol 1. Springer, Cham. https://doi.org/10.1007/15695_2017_6

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