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Techniques to Fabricate Electrospun Nanofibers for Controlled Release of Drugs and Biomolecules

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Electrospun Polymeric Nanofibers

Part of the book series: Advances in Polymer Science ((POLYMER,volume 291))

Abstract

Electrospinning is a nanotechnology-based platform with great potential in tissue engineering and related biomedical applications. The high surface-to-volume ratio of nanofibers makes them ideal candidates for the controlled delivery of drugs and biomolecules. The successful loading of multiple drugs and their controlled and sustained release at the targeted sites renders them suitable for guided tissue engineering applications. This chapter provides an overview of the electrospinning process and its advanced modification for successful encapsulation of drugs, biomolecules, and gene products to develop nanofiber-based therapeutic systems for biomedical applications, particularly focusing on the repair and regeneration of tissues. The gaps in the field and opportunities for future research are highlighted.

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Abbreviations

Ac-DEX:

Acetylated dextran

BMP-2:

Bone morphogenic protein-2

BSA:

Bovine serum albumin

DDS:

Drug delivery system

EGF:

Epidermal growth factor

FDA:

Food and drug association

HA:

Hydroxyapatite

MMP:

Matrix metalloprotein

NaAlg:

Sodium alginate

PCE:

Poly(ε-caprolactone)-co-poly(ethylene glycol)

PCE:

Polycarboxylate

PCL:

Poly (ε-caprolactone)

PDGF:

Platelet-derived growth factors

PdLA:

Poly(D, L-lactide)

PDLLA:

Poly(D, L-lactic acid)

PEG:

Poly(ethylene glycol)

PEI:

Poly(ethylenimine)

PEO:

Poly(ethylene oxide)

PGA:

Poly(glycolic acid)

PHBV:

Poly(hydroxybutyrate-co-hydroxyvalerate)

PLA:

Poly(lactic acid)

PLCL:

Poly(l-lactide-co- ε-caprolactone)

PLGA:

Poly(lactic-co-glycolic acid)

PLLA:

Poly (l-lactic acid)

PU:

Polyurethane

PVA:

Poly(vinyl alcohol)

PVP:

Polyvinylpyrrolidone

VEGF:

Vascular endothelial growth factors

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Acknowledgment

The authors acknowledge support from the Department of Science and Technology (DST), Government of India, (DST/NM/NB/2018/119(G)).

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  1. Department of Materials Engineering, Indian Institute of Science, Bangalore, Karnataka, India

    Monika Rajput, Suhela Tyeb & Kaushik Chatterjee

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  1. Monika Rajput
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Correspondence to Kaushik Chatterjee .

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  1. Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (University), Kochi, India

    R. Jayakumar

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Rajput, M., Tyeb, S., Chatterjee, K. (2022). Techniques to Fabricate Electrospun Nanofibers for Controlled Release of Drugs and Biomolecules. In: Jayakumar, R. (eds) Electrospun Polymeric Nanofibers. Advances in Polymer Science, vol 291. Springer, Cham. https://doi.org/10.1007/12_2022_140

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