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Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and Ca2+ Homeostasis

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Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 179))

Abstract

Cyclic AMP and Ca2+ are the first second or intracellular messengers identified, unveiling the cellular mechanisms activated by a plethora of extracellular signals, including hormones. Cyclic AMP generation is catalyzed by adenylyl cyclases (ACs), which convert ATP into cAMP and pyrophosphate. By the way, Ca2+, as energy, can neither be created nor be destroyed; Ca2+ can only be transported, from one compartment to another, or chelated by a variety of Ca2+-binding molecules. The fine regulation of cytosolic concentrations of cAMP and free Ca2+ is crucial in cell function and there is an intimate cross-talk between both messengers to fine-tune the cellular responses. Cancer is a multifactorial disease resulting from a combination of genetic and environmental factors. Frequent cases of cAMP and/or Ca2+ homeostasis remodeling have been described in cancer cells. In those tumoral cells, cAMP and Ca2+ signaling plays a crucial role in the development of hallmarks of cancer, including enhanced proliferation and migration, invasion, apoptosis resistance, or angiogenesis. This review summarizes the cross-talk between the ACs/cAMP and Ca2+ intracellular pathways with special attention to the functional and reciprocal regulation between Orai1 and AC8 in normal and cancer cells.

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Abbreviations

[Ca2+]c :

Cytosolic Ca2+ concentration

AC:

Adenylyl cyclase

ACBD3:

Acyl CoA binding domain protein-3

AKAP:

A-kinase anchoring protein

ARC:

Arachidonic acid-regulated Ca2+

CAD:

CRAC activation domain

CaM:

Calmodulin

CaMK:

Calmodulin-dependent kinase

CaN:

Calcineurin

CAP1:

Adenylyl cyclase-associated protein 1

CC:

Coiled-coil domain

CDI:

Ca2+-dependent inactivation

CRAC:

Ca2+ release-activated Ca2+

CTPD:

C-terminal polybasic domain

DRG:

Dorsal root ganglion

Epac:

Exchange factor directly activated by cAMP

ER:

Endoplasmic reticulum

FCDI:

Fast Ca2+-dependent inactivation

FRET:

Förster resonance energy transfer

GRK:

G-protein coupled receptor kinase

I CRAC :

Ca2+ released-activated Ca2+ current

IP3:

Inositol 1,4,5-trisphosphate

I SOC :

Store-operated Ca2+ currents

NCX:

Na+-Ca2+ exchanger

NFAT:

Nuclear factor of activated T-cells

OASF:

ORAI1-activating small fragment

PIP2:

Phosphatidylinositol 4,5-bisphosphate

PKA:

cAMP-dependent protein kinase

PKC:

Protein kinase C

PLC:

Phospholipase C

PM:

Plasma membrane

PMCA:

Plasma membrane Ca2+ ATPase

PTH:

Parathyroid hormone

RGS:

Regulator of G protein signaling

SAM :

Sterile alpha motif

SCDI:

Slow Ca2+-dependent inactivation

SERCA:

Sarco/endoplasmic reticulum Ca2+ ATPase

SOAR:

STIM1 Orai-activating region

SOC:

Store-operated channels

SOCE:

Store-operated Ca2+ entry

STIM1:

Stromal interaction molecule 1

TRP:

Transient receptor potential channels

TRPC:

Transient receptor potential-canonical

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Acknowledgements

This work was supported by MINECO (Grant BFU2016-74932-C2-1-P and PID2019-104084GB-C21) and Junta de Extremadura-Consejería de Economía e Infraestructura-FEDER (Fondo Europeo de Desarrollo Regional, Grants IB16046 and GR18061). We also thank Fundación Caja de Extremadura for its support. J.J.L. and I.J. are supported by a contract from Junta de Extremadura (TA18011 and TA18054, respectively). J.S.-C. is supported by a contract from Ministry of Science, Innovation, and Universities, Spain.

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  1. Jose Sanchez-Collado and Jose J. Lopez contributed equally to this work.

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  1. Department of Physiology and Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, Cáceres, Spain

    Jose Sanchez-Collado, Jose J. Lopez, Isaac Jardin, Gines M. Salido & Juan A. Rosado

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Sanchez-Collado, J., Lopez, J.J., Jardin, I., Salido, G.M., Rosado, J.A. (2020). Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and Ca2+ Homeostasis. In: Pedersen, S.H.F. (eds) Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 179. Springer, Cham. https://doi.org/10.1007/112_2020_55

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