Overview
- Describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them, based on state-of-the-art research
- The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties
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Table of contents (7 chapters)
Keywords
About this book
Molecules of biological interest for in-vivo and in-vitro research or diagnostics of metabolic functions and of neuro-transmission are very often labeled with iodine. Based on state-of-the-art research, this compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them.
The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They also include examples of important reaction pathways for the preparation of radio-iodine compounds. The volume is completed by an expert system providing guidelines to obtain the most suitable method of synthesis regarding also cost and time aspects. Worked examples support the novices confronted with radio-iodination reactions.
Reviews
From the reviews:
"This short book is a compendium of information on the preparation of radioiodine pharmaceuticals. It is … a collection of mature, well-tested ideas about the preparation of radioiodine pharmaceuticals. … this succinct volume may be of interest to the specialist in radiopharmaceutical preparation." (Walter Loveland, JACS, Vol. 128 (48), 2006)
Editors and Affiliations
Bibliographic Information
Book Title: Radioionidation Reactions for Pharmaceuticals
Book Subtitle: Compendium for Effective Synthesis Strategies
Editors: HEINZ H. COENEN, JOHN MERTENS, BERNARD MAZIEÈRE
DOI: https://doi.org/10.1007/1-4020-4561-1
Publisher: Springer Dordrecht
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Science+Business Media B.V. 2006
Hardcover ISBN: 978-1-4020-4560-8Published: 09 May 2006
Softcover ISBN: 978-90-481-7149-1Published: 18 November 2010
eBook ISBN: 978-1-4020-4561-5Published: 30 June 2006
Edition Number: 1
Number of Pages: XI, 101
Topics: Organic Chemistry, Analytical Chemistry, Physical Chemistry, Medicinal Chemistry