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Case report: human papilloma virus type 120-related papillomatosis mimicking laryngeal carcinoma

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Abstract

Introduction

The relationship between human papilloma virus (HPV) and upper respiratory tract pathology was better understood in recent years and represents now an issue of particular interest in carcinogenesis and in immunocompromised host. We describe a case in which a rare genotype HPV-related papillomatosis mimics laryngeal carcinoma in an immunocompromised host.

Methods

A 54-year-old woman with a history of HIV–HCV coinfection and anal and laryngeal cancer successfully treated some years before was hospitalized for severe dyspnea, cough and dysphagia. Fiberoptic endoscopic evaluation raised the suspicion of tumor relapse showing the presence of a large glottic-supraglottic ulcerated mass. Several laryngeal biopsies demonstrated koilocytosis and p16 expression, according to a possible HPV infection, and focal figures of mild dysplasia of epithelium. 18 F-FDG PET/CT did not show high glycolytic activity at laryngeal level. An invasive upper respiratory tract papillomatosis in an immunocompromised host was suspected because of the patient’s clinical improvement after antiretroviral therapy.

Conclusion

Pharyngeal swab and oral rinse harboured the same HPV120 genotype sequence, a betapapillomavirus of recent description and not yet related to any similar clinical presentations.

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Authors and Affiliations

  1. Department of Public Health and Infectious Diseases, “Sapienza” University of Rome, Via Giulio Cesare 41\B, 04100, Latina, Italy

    Valeria Belvisi, Cosmo Del Borgo & Claudio Maria Mastroianni

  2. Department of Surgical Biotechnologies and Sciences, ENT Section, “Sapienza” University of Rome, Latina, Italy

    Salvatore Martellucci, Stanislao Martellucci & Andrea Gallo

  3. Laboratory of Virology, I.N.M.I. “L. Spallanzani”, IRCCS, Rome, Italy

    Anna Rosa Garbuglia

  4. Pathology Service, I.N.M.I. “L. Spallanzani”, IRCCS, Rome, Italy

    Andrea Baiocchini

  5. Pathology Service, “S.M. Goretti” Hospital, Latina, Italy

    Anna Maria Manicone

  6. Department of Nuclear Medicine, “S.M. Goretti” Hospital, Latina, Italy

    Oreste Bagni

Authors
  1. Valeria Belvisi
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  2. Salvatore Martellucci
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  3. Anna Rosa Garbuglia
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  4. Cosmo Del Borgo
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  5. Stanislao Martellucci
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  6. Andrea Baiocchini
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  7. Anna Maria Manicone
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  8. Oreste Bagni
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  9. Claudio Maria Mastroianni
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  10. Andrea Gallo
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Corresponding author

Correspondence to Valeria Belvisi.

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The authors declare that they have no conflict of interests and certify that they have no affiliations with organizations with any financial or non-financial interest in the subject matter or materials discussed in this manuscript.

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Belvisi, V., Martellucci, S., Garbuglia, A.R. et al. Case report: human papilloma virus type 120-related papillomatosis mimicking laryngeal carcinoma. Infection 45, 709–713 (2017). https://doi.org/10.1007/s15010-017-1028-x

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  • DOI: https://doi.org/10.1007/s15010-017-1028-x

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