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Acute eosinophilic pneumonia is a non-infectious lung complication after allogeneic hematopoietic stem cell transplantation

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Abstract

Acute eosinophilic pneumonia (AEP) is an acute febrile illness with respiratory impairment, diffuse pulmonary infiltrates, and eosinophilia in bronchoalveolar lavage (BAL) fluid. We report an adult male who developed severe cough and dyspnea with slight fever on day 78 after allogeneic hematopoietic stem transplantation. The symptoms coexisted with skin and gut GVHD. The imaging test demonstrated interstitial infiltrates and BAL analysis revealed marked increase of eosinophils and no sign of infection. We made a diagnosis of AEP and steroid was started. AEP remitted with other GVHD symptoms but exacerbated partially when steroid was decreased. This case suggests a potential link between AEP and GVHD.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Mayumi Yoshimi, Yasuhito Nannya, Takuro Watanabe, Takashi Asai, Motoshi Ichikawa, Go Yamamoto, Akira Hangaishi, Yoichi Imai, Tsuyoshi Takahashi & Mineo Kurokawa

  2. Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan

    Keiki Kumano, Shigeru Chiba & Mineo Kurokawa

Authors
  1. Mayumi Yoshimi
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  2. Yasuhito Nannya
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  3. Takuro Watanabe
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  4. Takashi Asai
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  5. Motoshi Ichikawa
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  6. Go Yamamoto
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  7. Keiki Kumano
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  8. Akira Hangaishi
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  9. Yoichi Imai
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  10. Tsuyoshi Takahashi
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  11. Shigeru Chiba
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  12. Mineo Kurokawa
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Corresponding author

Correspondence to Mineo Kurokawa.

Additional information

M. Yoshimi and Y. Nannya authors contributed equally to this work.

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Yoshimi, M., Nannya, Y., Watanabe, T. et al. Acute eosinophilic pneumonia is a non-infectious lung complication after allogeneic hematopoietic stem cell transplantation. Int J Hematol 89, 244–248 (2009). https://doi.org/10.1007/s12185-008-0240-y

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  • DOI: https://doi.org/10.1007/s12185-008-0240-y

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