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Zerebrale Gadoliniumablagerungen bei der Magnetresonanztomographie des Herzens

Stellungnahme der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung

Cerebral gadolinium deposits in magnetic resonance imaging of the heart

Statement of the German Cardiac Society

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Literatur

  1. Weinmann HJ, Brasch RC, Press WR, Wesbey GE (1984) Characteristics of gadolinium-DTPA complex: A potential NMR contrast agent. AJR Am J Roentgenol 142(3):619–624

    Article  CAS  PubMed  Google Scholar 

  2. Bruder O, Schneider S, Pilz G, Rossum AC, Schwitter J, Nothnagel D et al (2015) Update on acute adverse reactions to gadolinium based contrast agents in cardiovascular MR. Large multi-national and multi-ethnical population experience with 37788 patients from the EuroCMR Registry. J Cardiovasc Magn Reson 17:1–7. doi:10.1186/s12968-015-0168-3

    Article  Google Scholar 

  3. Reiter T, Ritter O, Prince MR, Nordbeck P, Wanner C, Nagel E et al (2012) Minimizing risk of nephrogenic systemic fibrosis in cardiovascular magnetic resonance. J Cardiovasc Magn Reson 14:31

    Article  PubMed  PubMed Central  Google Scholar 

  4. Gibby WA, Gibby KA, Gibby WA (2004) Comparison of Gd DTPA-BMA (Omniscan) versus Gd HP-DO3A (ProHance) retention in human bone tissue by inductively coupled plasma atomic emission spectroscopy. Invest Radiol 39(3):138–142

    Article  PubMed  Google Scholar 

  5. White GW, Gibby WA, Tweedle MF (2006) Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy. Invest Radiol 41(3):272–278

    Article  PubMed  Google Scholar 

  6. Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D (2014) High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: Relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology 270(3):834–841

    Article  PubMed  Google Scholar 

  7. Jost G, Lenhard DC, Sieber MA, Lohrke J, Frenzel T, Pietsch H (2016) Signal increase on unenhanced T1-weighted images in the rat brain after repeated, extended doses of gadolinium-based contrast agents: comparison of linear and macrocyclic agents. Invest Radiol 51(2):83–89

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Robert P, Violas X, Grand S, Lehericy S, Idée J‑M, Ballet S et al (2016) Linear gadolinium-based contrast agents are associated with brain gadolinium retention in healthy rats. Invest Radiol 51(2):73–82

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Mamourian AC, Hoopes PJ, Lewis LD (2000) Visualization of intravenously administered contrast material in the CSF on fluid-attenuated inversion-recovery MR images: An in vitro and animal-model investigation. AJNR Am J Neuroradiol 21(1):105–111

    CAS  PubMed  Google Scholar 

  10. Kanda T, Fukusato T, Matsuda M, Toyoda K, Oba H, Kotoku J et al (2015) Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy. Radiology 276(1):228–232

    Article  PubMed  Google Scholar 

  11. McDonald RJ, McDonald JS, Kallmes DF, Jentoft ME, Murray DL, Thielen KR et al (2015) Intracranial gadolinium deposition after contrast-enhanced MR imaging. Radiology 275(3):772–782

    Article  PubMed  Google Scholar 

  12. Murata N, Gonzalez-Cuyar LF, Murata K, Fligner C, Dills R, Hippe D et al (2016) Macrocyclic and other non-group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: Preliminary results from 9 patients with normal renal function. Invest Radiol 51(7):447–453

    Article  CAS  PubMed  Google Scholar 

  13. Errante Y, Cirimele V, Mallio CA, Di Lazzaro V, Zobel BB, Quattrocchi CC (2014) Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol 49(10):685–690

    Article  CAS  PubMed  Google Scholar 

  14. Cao Y, Huang DQ, Shih G, Prince MR (2016) Signal change in the dentate nucleus on T1-weighted MR images after multiple administrations of Gadopentetate Dimeglumine versus Gadobutrol. AJR Am J Roentgenol 206(2):414–419

    Article  PubMed  Google Scholar 

  15. Kromrey M‑L, Liedtke KR, Ittermann T, Langner S, Kirsch M, Weitschies W et al (2016) Intravenous injection of Gadobutrol in an epidemiological study group did not lead to a difference in relative signal intensities of certain brain structures after 5 years. Eur Radiol. doi:10.1007/s00330-016-4418-z

    Google Scholar 

  16. Starr JM, Wardlaw J, Ferguson K, MacLullich A, Deary IJ, Marshall I (2003) Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging. J Neurol Neurosurg Psychiatr 74(1):70–76

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to E. Nagel.

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Den Interessenkonflikt der Autoren finden Sie online auf der DGK-Homepage unter http://leitlinien.dgk.org/ bei der entsprechenden Publikation.

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J. Lotz ist Vorsitzender der AG Herz- und Kreislauf der DRG

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Nagel, E., Lotz, J., Schulz-Menger, J. et al. Zerebrale Gadoliniumablagerungen bei der Magnetresonanztomographie des Herzens. Kardiologe 10, 371–373 (2016). https://doi.org/10.1007/s12181-016-0092-2

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  • DOI: https://doi.org/10.1007/s12181-016-0092-2

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