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Increased risk of new-onset type 2 diabetes in people with chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Purpose

This study investigated whether people with chronic kidney disease (CKD) are at the risk of new-onset type 2 diabetes.

Methods

A cohort comprising 16,624 people with CKD, and an age- and sex-matched control cohort of 66,496 persons without any clinical kidney disease were identified from the Taiwan National Health Insurance Database during the period of 2000–2010. Both cohorts were followed up to 2011 to evaluate the incidence and hazard ratio (HR) of developing new-onset type 2 diabetes. Diseases were identified based on diagnosis coding.

Results

The incidence of type 2 diabetes was 1.51-fold higher in the CKD cohort than in the control cohort (16.9 versus 11.2 per 1,000 person-years) with an adjusted hazard ratio of 1.17 (95% confidence interval, (CI)1.10–1.24). In the multivariate Cox regression model considering the competing-risk death, the adjusted subhazard ratio of type 2 diabetes was 1.30 (95% CI1.22–1.38) for the CKD cohort compared to the control cohort.

Conclusions

People with CKD patients are at an increased risk of developing new-onset type 2 diabetes. Close surveillance for diabetes should be considered for these people.

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Acknowledgements

This study is supported in part by Grants from the Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004), Children’s Hospital of China Medical University (DMR-105-041), China Medical University Hospital (DMR-107-026, DMR-107-176, and DMR-108-111), Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10601010036), Taiwan Clinical Trial Consortium for Stroke (MOST 107-2321-B-039-004), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan.

Author information

Author notes

  1. Tzu-Yuan Wang, Fung-Chang Sung have contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine, College of Medicine, China Medical University, Taichung, Taiwan

    I-Kuan Wang

  2. Division of Nephrology, China Medical University Hospital, Taichung, Taiwan

    I-Kuan Wang

  3. Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan

    Tsung-Hsun Tsai & Fung-Chang Sung

  4. Division of Urology, Department of Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan

    Tsung-Hsun Tsai

  5. Division of Endocrinology, China Medical University Hospital, Taichung, Taiwan

    Yi-Chih Hung & Tzu-Yuan Wang

  6. Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan

    Tzung-Hai Yen & Cheng-Li Lin

  7. Chang Gung University College of Medicine, Taoyuan, Taiwan

    Tzung-Hai Yen

  8. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    Fung-Chang Sung

  9. Department of Health Services Administration, China Medical University, 91 Hsueh Shih Road, Taichung, 404, Taiwan

    Fung-Chang Sung

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  1. I-Kuan Wang
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  2. Tsung-Hsun Tsai
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Correspondence to Fung-Chang Sung.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Wang, IK., Tsai, TH., Hung, YC. et al. Increased risk of new-onset type 2 diabetes in people with chronic kidney disease. Int Urol Nephrol 51, 707–712 (2019). https://doi.org/10.1007/s11255-019-02075-8

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  • DOI: https://doi.org/10.1007/s11255-019-02075-8

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