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Coupling tumor growth and bio distribution models

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Abstract

We couple a tumor growth model embedded in a microenvironment, with a bio distribution model able to simulate a whole organ. The growth model yields the evolution of tumor cell population, of the differential pressure between cell populations, of porosity of ECM, of consumption of nutrients due to tumor growth, of angiogenesis, and related growth factors as function of the locally available nutrient. The bio distribution model on the other hand operates on a frozen geometry but yields a much refined distribution of nutrient and other molecules. The combination of both models will enable simulating the growth of a tumor in a whole organ, including a realistic distribution of therapeutic agents and allow hence to evaluate the efficacy of these agents.

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Acknowledgements

B.A.S. gratefully acknowledges the support of the Technische Universität München - Institute for Advanced Study, funded by the German Excellence Initiative and the TUV SÜD Foundation. The authors acknowledge CITO Award, Houston Methodist Research Institute, Houston, NCI U54 CA210181. The authors affiliated to Serbian institutions also acknowledge support from Ministry of Education and Science of Serbia, grants OI 174028 and III 41007, and City of Kragujevac.

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Authors and Affiliations

  1. Department of Civil, Environmental and Architectural Engineering, University of Padova, via Marzolo 9, 35131, Padova, Italy

    Raffaella Santagiuliana & Bernhard A. Schrefler

  2. Bioengineering Research and Development Center BioIRC Kragujevac, Prvoslava Stojanovica 6, Kragujevac, 34000, Serbia

    Miljan Milosevic, Bogdan Milicevic, Vladimir Simic & Milos Kojic

  3. Belgrade Metropolitan University, Tadeuša Košćuška 63, Belgrade, 11000, Serbia

    Miljan Milosevic

  4. Institut de Mécanique et d’Ingénierie (I2M, CNRS UMR 5295), University of Bordeaux, Bordeaux, France

    Giuseppe Sciumè

  5. The Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave., R7 117, Houston, TX, 77030, USA

    Arturas Ziemys, Milos Kojic & Bernhard A. Schrefler

  6. Serbian Academy of Sciences and Arts, Knez Mihailova 35, Belgrade, 11000, Serbia

    Milos Kojic

  7. Institute for Advanced Study, Technische Universität München, Lichtenbergstrasse 2a, D-85748, Garching b. München, Germany

    Bernhard A. Schrefler

Authors
  1. Raffaella Santagiuliana
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  2. Miljan Milosevic
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  3. Bogdan Milicevic
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  4. Giuseppe Sciumè
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  5. Vladimir Simic
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  6. Arturas Ziemys
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  7. Milos Kojic
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  8. Bernhard A. Schrefler
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Correspondence to Raffaella Santagiuliana.

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Dedicated to Mauro Ferrari in occasion of his 60th birthday

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Santagiuliana, R., Milosevic, M., Milicevic, B. et al. Coupling tumor growth and bio distribution models. Biomed Microdevices 21, 33 (2019). https://doi.org/10.1007/s10544-019-0368-y

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  • DOI: https://doi.org/10.1007/s10544-019-0368-y

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