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Predictability of gastric intestinal metaplasia by patchy lavender color seen on linked color imaging endoscopy

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Abstract

We aimed to investigate the ability of linked color imaging (LCI) versus white light endoscopy (WLE) to detect gastric intestinal metaplasia (GIM). One hundred and seven participants who underwent upper gastrointestinal endoscopy were included. Under WLE endoscopy, biopsies were performed on any suspected abnormal mucosal changes. Under LCI endoscopy, we tested whether the specific color feature of patchy lavender color (PLC) pathologically indicated GIM. Biopsies were randomly performed in participants who had neither PLC nor suspected lesions. The detection abilities of LCI and WLE were assessed by comparison of histological and endoscopic findings. A total of 41 participants had histological GIM. The total diagnostic accuracy rate for GIM by LCI was 79.44%, higher than that of WLE (40.19%) (P < 0.001). Moreover, LCI with targeted biopsies showed a significantly increased ability to detect GIM (P < 0.001). PLC observed in the gastric mucosa on LCI can guide endoscopic biopsies and increase the detection rate of GIM. Thus, LCI could be a good tool for detecting GIM. ClinicalTrials.gov Identifier: ChiCTR-DDD-17011326)

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Funding

This study was supported by Guangzhou Science and Technology Project (grant number 201803010040), Guangdong Province Science and Technology plan project (No. 2017A010105004), and Guangdong Province Medical Science and Technology research fund project (No.A2017273).

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Authors and Affiliations

  1. Department of Gastrointestinal Endoscopy, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, People’s Republic of China

    Honglei Chen, Yanan Liu, Qiuning Wu, Yi Lu, Xutao Lin, Dejun Fan & Chujun Li

  2. Department of Gastrointestinal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, Guangdong, People’s Republic of China

    Huashe Wang

  3. Department of Gastrointestinal Surgery, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, Guangdong, People’s Republic of China

    Xiaobin Wu

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  1. Honglei Chen
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  9. Chujun Li
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Corresponding authors

Correspondence to Honglei Chen, Xiaobin Wu or Chujun Li.

Ethics declarations

The study was approved by the Ethics Committee of the Sixth Affiliated Hospital, Sun Yat-sen University and have been performed in accordance with the Declaration of Helsinki. The study was registered with Chinese Clinical Trial Registry (ChiCTR-DDD-17011381).

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Honglei Chen and Huashe Wang are the co-first author in this study.

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Chen, H., Wang, H., Wu, X. et al. Predictability of gastric intestinal metaplasia by patchy lavender color seen on linked color imaging endoscopy. Lasers Med Sci 34, 1791–1797 (2019). https://doi.org/10.1007/s10103-019-02775-8

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  • DOI: https://doi.org/10.1007/s10103-019-02775-8

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