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High positivity of anti-CCP antibodies in patients with Down syndrome

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Abstract

The aim of the present study was to evaluate the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in patients with Down’s syndrome (DS) previously tested for IgM rheumatoid factor (RF) and to correlate the results with clinical findings. Eighty-eight patients with DS previously tested for IgM-RF were divided into two groups matched for sex and age. Group A consists of 42 RF positive patients and group B of 44 RF negative patients. The presence of anti-CCP antibody was determined using a second-generation enzyme-linked immunosorbent assay. A total of 52.3% (45/86) of DS patients were positive for anti-CCP antibodies. Twenty-four patients (57.1%) of the RF positive group and 21 (47.7%) of the RF negative group presented anti-CCP circulating antibodies. The concordance between both tests was 54.6%. None of the patients had clinical evidence of rheumatoid arthritis or juvenile idiopathic arthritis. Although a high prevalence of anti-CCP antibodies was observed in DS patients, no association has been found presently with clinical disease. Careful follow-up of these patients will be necessary to clarify the real significance of these findings.

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Acknowledgment

This work was supported by a grant from the Araucária Foundation—Paraná. IJMR is a recipient of the Brazilian National Research Council CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) Research Fellowship (200936/2004-2).

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Authors and Affiliations

  1. Laboratory of Immunopathology, Department of Clinical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil

    Renato M. Nisihara, Iara T. Messias-Reason & Shirley R. R. Utiyama

  2. Rheumatology Clinic, Evangelic University Hospital of Curitiba, Curitiba, Brazil

    Thelma L. Skare & Marília B. G. Silva

  3. Down syndrome Clinic, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil

    Nanci P. Oliveira & Patricia T. Fiedler

  4. Ave. Arthur da Silva Bernardes, 753, Curitiba, Paraná, Brazil, 80 320 300

    Renato M. Nisihara

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  1. Renato M. Nisihara
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  2. Thelma L. Skare
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  3. Marília B. G. Silva
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  4. Iara T. Messias-Reason
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  5. Nanci P. Oliveira
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  6. Patricia T. Fiedler
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  7. Shirley R. R. Utiyama
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Correspondence to Renato M. Nisihara.

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Nisihara, R.M., Skare, T.L., Silva, M.B.G. et al. High positivity of anti-CCP antibodies in patients with Down syndrome. Clin Rheumatol 26, 2031–2035 (2007). https://doi.org/10.1007/s10067-007-0606-1

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  • DOI: https://doi.org/10.1007/s10067-007-0606-1

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