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Nanomaterial based electrochemical sensing of the biomarker serotonin: a comprehensive review

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Abstract

This review (with 131 references) summarizes the progress made in the past years in the field of nanomaterial based sensing of serotonin (5-HT). An introduction summarizes the significant role of 5-HT as a biomarker for several major diseases, methods for its determination and the various kinds of nanomaterials for use in electrochemical sensing process relies principally on a precise choice of electrodes. The next main section covers nanomaterial based methods for sensing 5-HT, with subsections on electrodes modified with carbon nanotubes, graphene related materials, gold nanomaterials, and by other nanomaterials. A concluding section discusses future perspectives and current challenges of 5-HT determination.

Conceptual design of electrochemical sensing process of the biomarker serotonin by using nanomaterials and the role of 5-HTas biomarker in the body from preclinical to clincal.

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Acknowledgements

This work was supported by Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences (Grant No. 1396-01-100-2249). The authors would like to express special thanks to Dr. Farshad Sharifi and Dr. Mahdi Khoshfetrat for their valuable insight.

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Authors and Affiliations

  1. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran

    Kamyar Khoshnevisan & Mohammad Reza Khorramizadeh

  2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran

    Kamyar Khoshnevisan, Bagher Larijani & Mohammad Reza Khorramizadeh

  3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755354, Iran

    Hassan Maleki & Reza Faridi Majidi

  4. Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, 13699-5810, USA

    Elham Honarvarfard

  5. Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran

    Hadi Baharifar

  6. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran

    Morteza Gholami

  7. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran

    Farnoush Faridbod

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  1. Kamyar Khoshnevisan
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Khoshnevisan, K., Maleki, H., Honarvarfard, E. et al. Nanomaterial based electrochemical sensing of the biomarker serotonin: a comprehensive review. Microchim Acta 186, 49 (2019). https://doi.org/10.1007/s00604-018-3069-y

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