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Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

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Abstract

To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarusian men aged 45–65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, and triglyceride concentrations were assessed, and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A1c, immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r = 0.23, P = 0.002) and leptin (r = 0.21, P = 0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (β = 0.058, P = 0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is necessary to confirm this association and to develop ways to correct abnormalities of bone metabolism in patients with T2DM.

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Acknowledgments

This work was supported by the Ministry of Education, Culture, Sports, Science, and Technology of Japan through the Nagasaki University Global COE program. We would also like to thank Miss Miho Yoshida for her technical assistance.

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Authors and Affiliations

  1. Department of Public Health, Gomel State Medical University, Gomel, Belarus

    Olga Vasilkova & Tamara Sharshakova

  2. The Republican Research Centre for Radiation Medicine and Human Ecology, Gomel, Belarus

    Olga Vasilkova

  3. Department of Internal Medicine, Belarussian State Medical University, Minsk, Belarus

    Tatiana Mokhort

  4. Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 8528523, Japan

    Naomi Hayashida & Noboru Takamura

Authors
  1. Olga Vasilkova
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  2. Tatiana Mokhort
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  5. Noboru Takamura
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Correspondence to Noboru Takamura.

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Vasilkova, O., Mokhort, T., Sharshakova, T. et al. Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus. Acta Diabetol 48, 291–295 (2011). https://doi.org/10.1007/s00592-011-0266-0

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  • DOI: https://doi.org/10.1007/s00592-011-0266-0

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