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Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature

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Abstract

Purpose

Testicular seminomas occur in young men and are highly curable. Toxicities following treatment for men with extensive stage II-III seminomas may cause long-term morbidities. However, it is not clear whether the risk of late effects also increases following surgery for testis-confined seminoma. In this systematic review, we examined the available literature regarding the incidence of late effects in our target population of patients with stage I seminoma treated with orchidectomy alone.

Method

Publications were identified through an electronic literature search using the MEDLINE, EMBASE and PsychInfo databases, identifying cohorts treated for stage I seminoma. Data on late effects were collected and classified as physical or psychological.

Results

Six hundred and four articles were screened to identify 100 studies. In the target population, available evidence suggests no increased risk of cardiovascular disease, metabolic syndrome, or renal dysfunction compared to the general population. Sperm counts were initially lower than an age-matched cohort; however, counts normalised when re-assessed 5 years later. Data were not specifically reported for the target population regarding bone health, second malignancy, hypogonadism, fertility and all psychological domains. Heterogeneity of study design and reporting methods contributed to uncertainty regarding the true incidence and clinical significance of late effects.

Conclusions

The curability of stage I seminoma and the wide range of potential late effects of treatment suggest the need for long-term monitoring alongside standard cancer surveillance. Important data are needed on the prevalence of late effects, specifically related to testicular cancer survivors undergoing surveillance following orchidectomy.

Implications for cancer survivors

Awareness and screening for relevant late effects may prevent further morbidity in men treated for stage I seminoma.

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Acknowledgements

IDD is supported by a National Health and Medical Research Council Practitioner Fellowship (APP1102604).

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Author notes

  1. Jennifer A. Soon and Angelyn Anton contributed equally to this work.

Authors and Affiliations

  1. Eastern Health Cancer Services, Level 4, 8 Arnold St., Box Hill, VIC, 3128, Australia

    Jennifer A. Soon, Angelyn Anton, Javier Torres, Phillip Parente, Joseph McKendrick, Ian D. Davis & Carmel Pezaro

  2. Eastern Health Library Services, 5 Arnold St., Box Hill, VIC, 3128, Australia

    Ruth Lawrence

  3. Monash University Eastern Health Clinical School, 5 Arnold St., Box Hill, VIC, 3128, Australia

    Phillip Parente, Joseph McKendrick, Ian D. Davis & Carmel Pezaro

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  1. Jennifer A. Soon
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Soon, J.A., Anton, A., Torres, J. et al. Exploring the spectrum of late effects following radical orchidectomy for stage I testicular seminoma: a systematic review of the literature. Support Care Cancer 27, 373–382 (2019). https://doi.org/10.1007/s00520-018-4492-7

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