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Stomach cancer mortality among workers exposed to asbestos: a meta-analysis

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

The relationship between asbestos and stomach cancer is not well understood because of small number of cases. This study aimed to determine the incidence and mortality of stomach cancer among workers exposed to asbestos based on a systematic review and meta-analysis approach.

Methods

Relevant English electronic databases were systematically searched for published studies characterizing the risk of developing stomach cancer as a result of asbestos exposure. Standardized mortality rate (SMR) for stomach cancer with its 95 % confidence interval (CI) was pooled using a fixed-/random-effect model in STATA.

Results

A total of 32 independent studies were included for the analysis. The overall SMR for stomach cancer was 1.19 (95 % CI 1.06–1.34), with a moderate degree of heterogeneity across the studies (I 2 = 37.6 %, P = 0.011). Being male, exposure to crocidolite, miners, studies conducted in Europe and Oceania, and long study follow-up (≥25 years) all contribute to significantly higher SMR. Significant publication bias was observed.

Conclusion

Elevated risk of stomach cancer mortality was evidenced among workers exposed to crocidolite, especially male miners.

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Acknowledgments

This work was financially supported by National Natural Science Foundation of China (71103002/41071064).

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The authors have declared that no conflict of interest exists.

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Correspondence to Xian-jie Jia or Lei Zhang.

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Peng, Wj., Jia, Xj., Wei, Bg. et al. Stomach cancer mortality among workers exposed to asbestos: a meta-analysis. J Cancer Res Clin Oncol 141, 1141–1149 (2015). https://doi.org/10.1007/s00432-014-1791-3

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  • DOI: https://doi.org/10.1007/s00432-014-1791-3

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