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Transgenic rice endosperm as a bioreactor for molecular pharming

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Abstract

Plants provide a promising expression platform for producing recombinant proteins with several advantages in terms of high expression level, lower production cost, scalability, and safety and environment-friendly. Molecular pharming has been recognized as an emerging industry with strategic importance that could play an important role in economic development and healthcare in China. Here, this review represents the significant advances using transgenic rice endosperm as bioreactor to produce various therapeutic recombinant proteins in transgenic rice endosperm and large-scale production of OsrHSA, and discusses the challenges to develop molecular pharming as an emerging industry with strategic importance in China.

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Authors and Affiliations

  1. College of Life Sciences, State Key Laboratory of Hybrid Rice, Wuhan University, Wuhan, China

    Jiquan Ou, Zhibin Guo, Xianghong Wang, Chufu Zhang & Daichnag Yang

  2. Hubei Engineering Research Center of Molecular Pharming, Wuhan Institute of Biotechnology, Biolake, Wuhan, China

    Jingni Shi, Jingru Liu & Bo Shi

  3. Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO, 64110, USA

    Fengli Guo

Authors
  1. Jiquan Ou
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  2. Zhibin Guo
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  3. Jingni Shi
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  4. Xianghong Wang
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  5. Jingru Liu
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  6. Bo Shi
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  7. Fengli Guo
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  8. Chufu Zhang
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  9. Daichnag Yang
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Corresponding author

Correspondence to Daichnag Yang.

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Communicated by N. Stewart.

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Ou, J., Guo, Z., Shi, J. et al. Transgenic rice endosperm as a bioreactor for molecular pharming. Plant Cell Rep 33, 585–594 (2014). https://doi.org/10.1007/s00299-013-1559-2

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  • DOI: https://doi.org/10.1007/s00299-013-1559-2

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