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Hydroperoxides derived from marine sources: origin and biological activities

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Abstract

Hydroperoxides are a small and interesting group of biologically active natural marine compounds. All these metabolites contain a group (R-O-O-H). In this mini-review, studies of more than 80 hydroperoxides isolated from bacteria, fungi, algae, and marine invertebrates are described. Hydroperoxides from the red, brown, and green algae exhibit high antineoplastic, anti-inflammatory, and antiprotozoal activity with a confidence of 73 to 94%. Hydroperoxides produced by soft corals showed antineoplastic and antiprotozoal activity with confidence from 81 to 92%. Metabolites derived from sea sponges, mollusks, and other invertebrates showed antineoplastic and antiprotozoal (Plasmodium) activity with confidence from 80 to 90%.

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Funding

The work was performed in the framework of the Program for Basic Research of Russian State Academies of Sciences for 2013-2020 (RFBR; V.V., student grant № 18-33-00651).

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Authors and Affiliations

  1. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991

    Vera A. Vil, Alexander O. Terent’ev & Valery M. Dembitsky

  2. Institute of Biomedical Chemistry, Moscow, Russia, 119991

    Tatyana A. Gloriozova

  3. Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada

    Nick Savidov & Valery M. Dembitsky

  4. Biochemical Laboratory, National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, Russia, 690041

    Valery M. Dembitsky

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  1. Vera A. Vil
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  2. Tatyana A. Gloriozova
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  3. Alexander O. Terent’ev
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  4. Nick Savidov
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  5. Valery M. Dembitsky
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Correspondence to Valery M. Dembitsky.

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Vil, V.A., Gloriozova, T.A., Terent’ev, A.O. et al. Hydroperoxides derived from marine sources: origin and biological activities. Appl Microbiol Biotechnol 103, 1627–1642 (2019). https://doi.org/10.1007/s00253-018-9560-x

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