Abstract
A dual way to turn temperature increase into account to improve hyperthermia was investigated. Application of intracellular heating by magnetoliposomes, enabled us to enhance expression of interferon- β gene regulated by the MMTV promoter. The expression obtained in an 39°C environment was higher than that in extracellular heating at 43°C. Cell killing effect was also raised by intracellular heating although this effect was not directly proportional to the cellular expression of IFN-β.
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© 1998 Springer Science+Business Media Dordrecht
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Bouhon, I.A., Shinkai, M., Honda, H., Kobayashi, T. (1998). Magnetoliposomes as Intracellular Heat Stress Mediators for the Temperature Sensitive Expression of Cytokine. In: Nagai, K., Wachi, M. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5161-0_61
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DOI: https://doi.org/10.1007/978-94-011-5161-0_61
Publisher Name: Springer, Dordrecht
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