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Use of Probiotics for Dermal Applications

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Book cover Probiotics

Part of the book series: Microbiology Monographs ((MICROMONO,volume 21))

Abstract

The concept of probiotic bacteria is considerably evolving. Clinical and experimental researches extensively document that beyond probiotic capacity to influence positively the intestinal functions, they can exert their benefits at the skin level thanks to their peculiar properties. Indeed, scientific and evidence-based reports strengthen the assumption that certain probiotics can contribute to modulate cutaneous microflora, lipid barrier, and skin immune system, leading to the preservation of the skin homeostasis. In this chapter, the most relevant evidences available from scientific literature as well as registered patents have been summarized in relation to actual or potential topical applications of probiotics in the field of dermatology. Altogether the evidences reported in this review afford the possibility of designing new strategies based on a topical approach for the prevention and treatment of cutaneous disorders.

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References

  • Al-Ghazzewi FH, Tester RF (2009) Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro. Int J Cosmet Sci 32:139–142

    Article  PubMed  Google Scholar 

  • Arck P, Handjiski B, Hagen E, Pincus M, Bruenahl C, Bienenstock J, Paus R (2010) Is there a ‘gut-brain-skin axis’? Exp Dermatol 19:401–405

    Article  PubMed  Google Scholar 

  • Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63:8–18

    Article  PubMed  CAS  Google Scholar 

  • Asong J, Wolfert MA, Maiti KK, Miller D, Boons GJ (2009) Binding and cellular activation studies reveal that Toll-like receptor 2 can differentially recognize peptidoglycan from gram-positive and gram-negative bacteria. J Biol Chem 284:8643–8653

    Article  PubMed  CAS  Google Scholar 

  • Baba H, Masuyama A, Takano T (2006) Effects of Lactobacillus helveticus-fermented milk on the differentiation of cultured normal human epidermal keratinocytes. J Dairy Sci 89:2072–2075

    Article  PubMed  CAS  Google Scholar 

  • Bleau C, Savard R, Lamontagne L (2007) Murine immunomodulation of IL-10 and IL-12 induced by new isolates from avian type 2 Lactobacillus acidophilus. Can J Microbiol 53:944–956

    Article  PubMed  CAS  Google Scholar 

  • Bouilly-Gauthier D, Jeannes C, Maubert Y, Duteil L, Queille-Roussel C, Piccardi N, Montastier C, Manissier P, Piérard G, Ortonne JP (2010) Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage. Br J Dermatol 163:534–543

    Article  Google Scholar 

  • Bruch-Gerharz D, Ruzicka T, Kolb-Bachofen V (1998) Nitric oxide in human skin: current status and future prospects. Investig Dermatol 110:1–7

    Article  CAS  Google Scholar 

  • Caramia G, Atzei A, Fanos V (2008) Probiotics and the skin. Clin Dermatol 26:4–11

    Article  PubMed  Google Scholar 

  • Castiel I, Gueniche A (2009) Cosmetic use of microorganisms. WO Patent 031099 A2, 12 Mar 2009

    Google Scholar 

  • Cavaliere widow Vesely RMA, De Simone C (2001) Sphinogomyelinase composition and use thereof. US patent 6,258,355 B1, 10 Jul 2001

    Google Scholar 

  • Chiba K (2007) Development of functional cosmetic ingredients using lactic acid bacteria in Japan. Jpn J Lactic Acid Bact 18:105–112

    Article  CAS  Google Scholar 

  • Chong BF, Blank LM, Mclaughlin R, Nielsen LK (2005) Microbial hyaluronic acid production. Appl Microbiol Biotechnol 66:341–351

    Article  PubMed  CAS  Google Scholar 

  • Cinque B, Di Marzio L, Della Riccia DN, Bizzini F, Giuliani M, Fanini D, De Simone C, Cifone MG (2006) Effect of Bifidobacterium infantis on Interferon-gamma-induced keratinocyte apoptosis: a potential therapeutic approach to skin immune abnormalities. Int J Immunopathol Pharmacol 19:775–786

    PubMed  CAS  Google Scholar 

  • Cinque B, Palumbo P, La Torre C, Melchiorre E, Corridoni D, Miconi G, Di Marzio L, Cifone MG, Giuliani M (2010) Probiotics in aging skin. In: Textbook of aging skin. Springer, Berlin, pp 811–819

    Chapter  Google Scholar 

  • Clark RA (2010) Skin resident T cells: the ups and downs of on site immunity. Invest Dermatol 130:362–370

    Article  CAS  Google Scholar 

  • de Roock S, van Elk M, van Dijk ME, Timmerman HM, Rijkers GT, Prakken BJ, Hoekstra MO, de Kleer IM (2010) Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humans. Clin Exp Allergy 40:103–110

    PubMed  Google Scholar 

  • De Simone C (2003) Use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction and pharmaceutical or dietetic compositions containing such bacteria. US Patent 0215429 A1, 20 Nov 2003

    Google Scholar 

  • Della Riccia DN, Bizzini F, Perilli MG, Polimeni A, Trinchieri V, Amicosante G, Cifone MG (2007) Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease. Oral Dis 13:376–385

    Article  Google Scholar 

  • Di Marzio L, Cinque B, De Simone C, Cifone MG (1999) Effect of lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. J Invest Dermatol 113:98–106

    Article  PubMed  Google Scholar 

  • Di Marzio L, Russo FP, D’Alò S, Biordi L, Ulisse S, Amicosante G, De Simone C, Cifone MG (2001) Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities. Nutr Cancer 40:185–196

    Article  PubMed  Google Scholar 

  • Di Marzio L, Centi C, Cinque B, Masci S, Giuliani M, Arcieri A, Zicari L, De Simone C, Cifone MG (2003) Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. Exp Dermatol 12:615–620

    Article  PubMed  Google Scholar 

  • Di Marzio L, Cinque B, Cupelli F, De Simone C, Cifone MG, Giuliani M (2008) Increase of skin-ceramide levels in aged subjects following a short-term topical application of bacterial sphingomyelinase from Streptococcus thermophilus. Int J Immunopathol Pharmacol 21(1):137–143

    PubMed  Google Scholar 

  • Farmer S (2005) Topical compositions containing probiotic bacillus bacteria, spores, and extracellular products and uses thereof. US Patent 6905692, 14 June 2005

    Google Scholar 

  • Feingold KR (2007) Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis. J Lipid Res 48:2531–2546

    Article  PubMed  CAS  Google Scholar 

  • Gillor O, Etzion A, Riley MA (2008) The dual role of bacteriocins as anti- and probiotics. Appl Microbiol Biotechnol 81:591–606

    Article  PubMed  CAS  Google Scholar 

  • Greul AK, Grundmann JU, Heinrich F, Pfitzner I, Bernhardt J, Ambach A, Biesalski HK, Gollnick H (2002) Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol 15:307–315

    PubMed  CAS  Google Scholar 

  • Guan R, Mariuzza RA (2007) Peptidoglycan recognition proteins of the innate immune system. Trends Microbiol 15:127–134

    Article  PubMed  CAS  Google Scholar 

  • Gueniche A (2010) Use of probiotic microorganisms to limit skin irritation. US Patent 0226892 A1, 9 Sept 2010

    Google Scholar 

  • Gueniche A, Castiel I (2009) Use of combination of hesperidin and of a microorganism for influencing the barrier function of the skin. US Patent 00681161 A1, 12 Mar 2009

    Google Scholar 

  • Gueniche A, Benyacoub J, Buetler TM, Smola H, Blum S (2006a) Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure. Eur J Dermatol 16:511–517

    PubMed  Google Scholar 

  • Gueniche A, Breton L, Ballevre O, Blum-Sperise S, Bureau-Franz I, Benyacoub J (2006b) Cosmetic and/or dermatological composition for sensitive skin. US Patent 0171936 A1, 3 Aug 2006

    Google Scholar 

  • Gueniche A, Buetler T, Benyacoub J, Blum S (2008) Lactobacillus johnsonii provides a dose-dependent protection against UVR-induced immunosuppression. Eur J Dermatol 18:476–477

    PubMed  Google Scholar 

  • Gueniche A, Bastien P, Ovigne JM, Kermici M, Courchay G, Chevalier V, Breton L, Castiel-Higounenc I (2010b) Bifidobacterium longum lysate, a new ingredient for reactive skin. Exp Dermatol 19:e1–e8

    Article  PubMed  Google Scholar 

  • Gueniche A, Benyacoub J, Philippe D, Bastien P, Kusy N, Breton L, Blum S, Castiel-Higounenc I (2010a) Lactobacillus paracasei CNCM I-2116 (ST11) inhibits substance P-induced skin inflammation and accelerates skin barrier function recovery in vitro. Eur J Dermatol 20(6):731–737

    PubMed  Google Scholar 

  • Halper J, Leshin LS, Lewis SJ, Li WI (2003) Wound healing and angiogenic properties of supernatants from Lactobacillus cultures. Exp Biol Med 228:1329–1337

    CAS  Google Scholar 

  • Hansen JE, Jespersen LK (2010) Wound or tissue dressing comprising lactic acid bacteria. US Patent 0143447 A1, 10 June 2010

    Google Scholar 

  • Izawa N, Hanamizu T, Sone T, Chiba K (2010) Effects of fermentation conditions and soybean peptide supplementation on hyaluronic acid production by Streptococcus thermophilus strain YIT 2084 in milk. J Biosci Bioengn 109:356–360

    Article  CAS  Google Scholar 

  • Jones ML, Ganopolsky JG, Labbé A, Prakash S (2010) A novel nitric oxide producing probiotic patch and its antimicrobial efficacy: preparation and in vitro analysis. Appl Microbiol Biotechnol 87:509–516

    Article  PubMed  CAS  Google Scholar 

  • Klaenhammer TR (1993) Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev 2:39–85

    Google Scholar 

  • Kodali VP, Sen R (2008) Antioxidant and free radical scavenging activities of an exopolysaccharide from a probiotic bacterium. Biotechnol J 3:245–251

    Article  PubMed  CAS  Google Scholar 

  • Krutmann J (2009) Pre- and probiotics for human skin. J Dermatol Sci 54:1–5

    Article  PubMed  Google Scholar 

  • Kullisaar T, Songisepp E, Mikelsaar M, Zilmer K, Vihalemm T, Zilmer M (2003) Antioxidative probiotic fermented goats’ milk decreases oxidative stress-mediated atherogenicity in human subjects. Br J Nutr 90:449–456

    Article  PubMed  CAS  Google Scholar 

  • Lambers H, Piessens S, Bloem A, Pronk H, Finkel P (2006) Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci 28:359–370

    Article  PubMed  CAS  Google Scholar 

  • Lieurey S, Watkins K (2009) Use of fermented milk product for skin treatment. US Patent 0252812 A1, 8 Oct 2008

    Google Scholar 

  • Lin MY, Chang FJ (2000) Antioxidative effect of intestinal bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356. Dig Dis Sci 45:1617–1622

    Article  PubMed  CAS  Google Scholar 

  • Lin MY, Yen CL (1999) Antioxidative ability of lactic acid bacteria. J Agric Food Chem 47:1460–1466

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto S, Hara T, Nagaoka M, Mike A, Mitsuyama K, Sako T, Yamamoto M, Kado S, Takada T (2009) A component of polysaccharide peptidoglycan complex on Lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer. Immunology 128:e170–e180

    Article  PubMed  CAS  Google Scholar 

  • Mauro T (2006) SC pH: measurement, origins, and functions. In: Elias P, Feingold K (eds) Skin barrier. Taylor & Francis, New York, pp 223–229

    Google Scholar 

  • Miyazaki K, Hanamizu T, Iizuka R, Chiba K (2003) Bifidobacterium-fermented soy milk extract stimulates hyaluronic acid production in human skin cells and hairless mouse skin. Skin Pharmacol Appl Skin Physiol 16:108–116

    PubMed  CAS  Google Scholar 

  • Miyazaki K, Hanamizu T, Sone T, Chiba K, Kinoshita T, Yoshikawa S (2004) Topical application of Bifidobacterium-fermented soy milk extract containing genistein and daidzein improves rheological and physiological properties of skin. J Cosmet Sci 55:473–479

    PubMed  CAS  Google Scholar 

  • Mizutani Y, Mitsutake S, Tsuji K, Kihara A, Igarashi Y (2009) Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie 91:784–790

    Article  PubMed  CAS  Google Scholar 

  • Oelschlaeger TA (2010) Mechanisms of probiotic actions – a review. Int J Med Microbiol 300:57–62

    Article  PubMed  CAS  Google Scholar 

  • Oh S, Kim SH, Ko Y, Sim JH, Kim KS, Lee SH, Park S, Kim YJ (2006) Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria. Food Chem Toxicol 44:552–559

    Article  PubMed  CAS  Google Scholar 

  • Peguet-Navarro J, Dezutter-Dambuyant C, Buetler T, Leclaire J, Smola H, Blum S, Bastien P, Breton L, Gueniche A (2008) Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial. Eur J Dermatol 18:504–511

    PubMed  CAS  Google Scholar 

  • Peral MC, Martinez MA, Valdez JC (2009a) Bacteriotherapy with Lactobacillus plantarum in burns. Int Wound J 6:73–81

    Article  PubMed  Google Scholar 

  • Peral MC, Rachid MM, Gobbato NM, Huaman Martinez MA, Valdez JC (2009b) Interleukin-8 production by polymorphonuclear leukocytes from patients with chronic infected leg ulcers treated with Lactobacillus plantarum. Clin Microbiol Infect 16:281–286

    Article  PubMed  Google Scholar 

  • Peran L, Camuesco D, Comalada M, Nieto A, Concha A, Adrio JL, Olivares M, XausJ ZA, Galvez J (2006) Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis. Int J Colorectal Dis 21:737–746

    Article  PubMed  Google Scholar 

  • Rittié L, Fisher GJ (2002) UV-light-induced signal cascades and skin aging. Ageing Res Rev 1:705–720

    Article  PubMed  Google Scholar 

  • Shen Q, Zhang B, Xu R, Wang Y, Ding X, Li P (2010) Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. Anaerobe 16:380–386

    Article  PubMed  CAS  Google Scholar 

  • Shida K, Kiyoshima-Shibata J, Nagaoka M, Watanabe K, Nanno M (2006) Induction of interleukin-12 by Lactobacillus strains having a rigid cell wall resistant to intracellular digestion. J Dairy Sci 89:3306–3317

    Article  PubMed  CAS  Google Scholar 

  • Simmering R, Breves R (2009) Pre- and probiotic cosmetics. Hautarzt 60:809–814

    Article  PubMed  CAS  Google Scholar 

  • Spigelman M, Ross M (2008) Method of using topical probiotics for the inhibition of surface contamination by a pathogenic microorganisms and composition therefor. US Patent 0107699 A1, 8 May 2008

    Google Scholar 

  • Sullivan M, Schnittger SF, Mammone T, Goyarts EC (2009). Skin treatment method with Lactobacillus extract. US Patent 7,510,734 B2, 31 Mar 2009

    Google Scholar 

  • Sun J, Shi YH, Le GW, Ma XY (2005) Distinct immune response induced by peptidoglycan derived from Lactobacillus sp. World J Gastroenterol 11:6330–6337

    PubMed  CAS  Google Scholar 

  • Teodorescu R (1999) A natural eubiotic product for maintenance and treatment of teguments. WO Patent 007332, 18 Feb 1999

    Google Scholar 

  • Terahara M, Kurama S, Takemoto N (2001) Prevention by lactic acid bacteria of the oxidation of human LDL. Biosci Biotechnol Biochem 65:1864–1868

    Article  PubMed  CAS  Google Scholar 

  • Teraki Y, Shiohara T (2003) IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption. J Allergy Clin Immunol 112:609–615

    Article  PubMed  CAS  Google Scholar 

  • Trautmann A, Akdis M, Schmid-Grendelmeier P, Disch R, Bröcker EB, Blaser K, Akdis CA (2001) Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. J Allergy Clin Immunol 108:839–846

    Article  PubMed  CAS  Google Scholar 

  • Valdéz JC, Peral MC, Rachid M, Santana M, Perdigón G (2005) Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect 11:472–479

    Article  PubMed  Google Scholar 

  • Volz T, Biedermann T (2009) Outside-in. Probiotic topical agents Hautarzt 60:795–801

    Article  CAS  Google Scholar 

  • Vukmanovic-Stejic M, Agius E, Booth N, Dunne PJ, Lacy KE, Reed JR, Sobande TO, Kissane S, Salmon M, Rustin MH, Akbar AN (2008) The kinetics of CD4 + Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J Clin Invest 118:3639–3650

    Article  PubMed  CAS  Google Scholar 

  • Williams NT (2010) Probiotics. Am J Health Syst Pharm 67:449–458

    Article  PubMed  CAS  Google Scholar 

  • Xu Y, Fisher GJ (2005) Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging. J Dermatol Sci Suppl 1:S1–S8

    Google Scholar 

  • Yadav H, Jain S, Sinha PR (2007) Production of free fatty acids and conjugated linoleic acid in probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei during fermentation and storage. Int Dairy J 17:1006–1010

    Article  CAS  Google Scholar 

  • Zeuthen LH, Fink LN, Frøkiaer H (2008) Toll-like receptor 2 and nucleotide-binding oligomerization domain-2 play divergent roles in the recognition of gut-derived lactobacilli and bifidobacteria in dendritic cells. Immunology 124:489–502

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Health’s Sciences, University of L’Aquila, 67100, Coppito, L’Aquila, Italy

    Benedetta Cinque, Cristina La Torre, Esterina Melchiorre, Giuseppe Marchesani, Giovanni Zoccali, Paola Palumbo, Maurizio Giuliani & Maria Grazia Cifone

  2. Department of Drug Sciences, University of Chieti-Pescara Gabriele D’Annunzio, Via dei Vestini, 66013, Chieti, Italy

    Luisa Di Marzio

  3. Department of Biochemical Sciences, Sapienza University, p.le Aldo Moro, 5, 00185, Rome, Italy

    Alessandra Masci & Luciana Mosca

  4. Department of Public Health and Infectious Diseases, Section of Microbiology, Sapienza University, p.le Aldo Moro, 5, 00185, Rome, Italy

    Paola Mastromarino

Authors
  1. Benedetta Cinque
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  2. Cristina La Torre
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  3. Esterina Melchiorre
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  4. Giuseppe Marchesani
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  5. Giovanni Zoccali
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  6. Paola Palumbo
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  7. Luisa Di Marzio
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  8. Alessandra Masci
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  9. Luciana Mosca
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  10. Paola Mastromarino
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  11. Maurizio Giuliani
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  12. Maria Grazia Cifone
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Correspondence to Maria Grazia Cifone .

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  1. , School of Industrial Technology, University Sains Malaysia, Penang, 11800, Malaysia

    Min-Tze Liong

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Cinque, B. et al. (2011). Use of Probiotics for Dermal Applications. In: Liong, MT. (eds) Probiotics. Microbiology Monographs, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20838-6_9

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