Skip to main content
SpringerLink
Log in

Environmental and Genetic Factors in Facial Aging in Twins

  • Reference work entry
Textbook of Aging Skin

Abstract

The etiologic factors contributing to facial senescence have been investigated for decades if not centuries. In essence, the causes of facial aging can be divided into two broad categories: intrinsic and extrinsic [1]. Intrinsic aging is that which occurs as a response to the deterioration of tissues over time [2]. This process is ubiquitous throughout all organs and tissues, although the methods of “deterioration” may vary from system to system. Intrinsic changes of the face include those to the skin, subcutaneous tissue, dermal appendages, facial musculature, as well as the facial skeleton. The process of extrinsic facial aging is, theoretically, a distinct entity. Typically, extrinsic aging is induced by external factors, such as UV radiation, causing progressive damage at both the molecular and cellular levels. Unlike intrinsic aging, most extrinsic factors exert their effect at the skin level only.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 499.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Uitto J. Understanding premature skin aging. New Eng J Med. 1997;337:1419–1428.

    Article  Google Scholar 

  2. Leung W, Harvey I. Is skin ageing in the elderly caused by sun exposure or smoking? Br J Dermatol. 2002;147(6):1187–1191.

    Article  PubMed  Google Scholar 

  3. Pesce K, Rothe M. The premature aging syndromes. Clin Dermatol. 1996;14:161–170.

    Article  CAS  PubMed  Google Scholar 

  4. Solly S. Clinical lectures on paralysis. Lancet. 1856;130(2):167–173.

    Google Scholar 

  5. O’Hare P, et al. Tobacco smoking contributes little to facial wrinkling. J Eur Acad Dermatol Venereol. 1999;12(2):133–139.

    Article  PubMed  Google Scholar 

  6. Allen H, Johnson B. Diamond S Smokers wrinkles? JAMA. 1973;225:1067–1069.

    Article  CAS  PubMed  Google Scholar 

  7. Daniell H. A study in the epidemiology of ‘crows feet’. Ann Intern Med. 1971;75(6):873–880.

    CAS  PubMed  Google Scholar 

  8. Model D. Smoker’s face: an underrated clinical sign? BMJ. 1985;291(6511):1760–1763.

    Article  CAS  PubMed  Google Scholar 

  9. Ernster V, et al. Facial wrinkling in men and women, by smoking status. Am J Public Health. 1995;85:78–82.

    Article  CAS  PubMed  Google Scholar 

  10. Keadunce D, et al. Cigarette smoking: risk factor for premature facial wrinkling. Ann Intern Med. 1991;114(10):840–844.

    Google Scholar 

  11. Chung J, et al. Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color. Arch Dermatol. 2001;137(8):1043–1051.

    CAS  PubMed  Google Scholar 

  12. Helfrich Y, et al. Effect of smoking on aging of photoprotected skin: evidence gatheres using a new photonumeric scale. Arch Dermatol. 2007;143(5):397–402.

    Article  PubMed  Google Scholar 

  13. Doshi D, Hanneman K, Cooper K. Smoking and skin aging in identical twins. Arch Dermatol. 2007;143(12):1543–1546.

    Article  PubMed  Google Scholar 

  14. Antell D, Taczanowski E. How environment and lifestyle choices influence the aging process. Ann Plast Surg. 1999;43:585–588.

    Article  CAS  PubMed  Google Scholar 

  15. Rexbye H, et al. Influence of environmental factors on facial ageing. Age Ageing. 2006;35(2):110–115.

    Article  PubMed  Google Scholar 

  16. Guyuron B, et al. Factors contributing to the facial aging of identical twins. Plast Reconstr Surg. 2009;123:1–11.

    Article  Google Scholar 

  17. Lahmann C, et al. Matrix Metalloproteinase-1 and skin ageing in smokers. Lancet. 2001;357:935–936.

    Article  CAS  PubMed  Google Scholar 

  18. Fisher G, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462–1470.

    Article  CAS  PubMed  Google Scholar 

  19. Sohal R, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996;273:59–63.

    Article  CAS  PubMed  Google Scholar 

  20. Fisher G, et al. Pathophysiology of premature skin aging by ultraviolet light. New Engl J Med. 1997;337:1463–1465.

    Article  Google Scholar 

  21. Guinot C, et al. Relative contribution of intrinsic vs extrinsic factors to skin aging as determined by a validated skin age score. Arch Dermatol. 2002;138(11):1454–1460.

    Article  PubMed  Google Scholar 

  22. Purba M, et al. Can skin wrinkling in a site that has received limited sun exposure be used as a marker of health status and biological age? Age Ageing. 2001;30:227–234.

    Article  CAS  PubMed  Google Scholar 

  23. Pierard G, et al. Effect of hormone replacement therapy for menopause on the mechanical properties of the skin. J Am Geriatr Soc. 1995;43(6):662–665.

    CAS  PubMed  Google Scholar 

  24. Callens A, et al. Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology. 1996;193(4):289–294.

    Article  CAS  PubMed  Google Scholar 

  25. Nilsson P, et al. Adverse social factors predict early ageing in middle-aged men and women: the Ebeltoft Health Study, Denmark. Scand J Public Health. 2003;31(4):255–260.

    Article  PubMed  Google Scholar 

  26. Demakakos P, et al. Socioeconomic status and health: the role of subjective social status. Soc Sci Med. 2008;67(2):330–340.

    Article  PubMed  Google Scholar 

  27. Osler M, et al. Marital status and twins’ health and behavior: an analysis of middle-aged Danish twins. Psychosom Med. 2008;70(4):482–487.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Hospitals, Case Western Reserve University, Cleveland, OH, USA

    David J. Rowe

  2. Department of Plastic Surgery, University Hospitals of Cleveland and Case, Western Reserve University, Cleveland, OH, USA

    Bahman Guyuron

Authors
  1. David J. Rowe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bahman Guyuron
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Rowe, D.J., Guyuron, B. (2010). Environmental and Genetic Factors in Facial Aging in Twins. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_45

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-89656-2_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation