Abstract
In this paper possible applications of the Perturbed Angular Correlations (PAC) technique in Biology are considered. Previous PAC experiments in biology are globally analyzed. All the work that appears in the literature has been grouped in a few research lines, just to make the analysis and discussion easy. The commonly used radioactive probes are listed and the experimental difficulties are analyzed. We also report applications of 181Hf and 111In isotopes in life sciences other than their use in PAC. The possibility of extending these studies using the PAC technique is discussed.
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References
Leipert, T.K., Baldeschwieler, J.D., Shirley, D.A.: Applications of gamma ray angular correlations to the study of biological macromolecules in solution. Nature 220, 907–909 (1968)
Meares, C.F., Sundberg, M.W., Baldeschwieler, J.D.: Perturbed angular correlation study of a haptenic molecule. Proc. Nat. Acad. Sci. U. S. A. 69, 3718–3722 (1972)
Bauer, R., Limkilde, P., Johansen, J.T.: Low and high pH form of cadmium carbonic anhydrase determined by nuclear quadrupole interaction. Biochemistry 15, 334–342 (1976)
Hemmingsen, L., Sas, K.N., Danielsen, E.: Biological applications of perturbed angular correlations of y-ray spectroscopy. Chem. Rev. 104, 4027–4061 (2004)
Bodenstedt, E.: Concluding remarks. Hyperfine Interact. 16, 1061–1068 (1983)
Glennas, A., Rugstad, H.E.: Cadmiun uptake and metabolism in cultured cells. Environ. Health Perspect. 54, 45–50 (1984)
Kruse, C.A., Tin, G.W., Baldeschwieler, J.D.: Stability of erythrocyte ghosts: a gamma-ray perturbed angular correlation study. Proc. Nat. Acad. Sci. U. S. A. 80, 1212–1216 (1983)
Bauer, R.: Perturbed angular correlation spectroscopy and its application to metal sites in proteins: possibilities and limitations. Q. Rev. Biophys. 18, 1–64 (1985)
Bode, P.: A future for nuclear analytical techniques? Why not? Anal. Bioanal. Chem. 379, 181–187 (2004)
Butz, T.: TDPAC research in the border region of physics, chemistry, biology: charge density waves, intercalation reactions, and metal proteins. Hyperfine Interact. 84, 47–64 (1994)
Troger, W.: Nuclear probes in life sciences. Hyperfine Interact. 120–121, 117–128 (1999)
Shpinkova, L.G., Sorokin, A.A., Komissarova, B.A., Ryasnyi, G.K., Kulakov, V.N., Nikitin, S.M.: Application of perturbed angular y-ray correlations in medical chemistry. Meas. Tech. 42, 490–501 (1999)
Troger, W., Butz, T.: Inorganic biochemistry with short-lived radioisotopes as nuclear probes. Hyperfine Interact. 129, 511–527 (2000)
Bakka, A., Eriksen, D.O., Rugstad, H.E., Bauer, R.: Identification of cadmiun binding sites within living human cells by perturbed angular correlation spectroscopy. FEBS Lett. 139, 57–60 (1982)
De Bruin, M., Bode, P., Wolterbeek, H.: Studies of trace element transport in plants using high resolution y-ray spectroscopy and perturbed directional correlation measurements. J. Radioanal. Nucl. Chem. 110, 365–372 (1987)
Reilly, R.M., Chen, P., Wang, J., Scollard, D., Cameron, R., Vallis, K.A.: Preclinical pharmacokinetic, biodistribution, toxicology, and dosimetry studies of 111In-DTPA-human epidermal growth factor: an auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer. J. Nucl. Med. 47, 1023–1031 (2006)
Thakur, M., Coss, R., Howell, R., Vassileva-Belnikolovska, D., Liu, J., Rao, S., Spana, G., Wachsberger, P., Leeper, D.: Role of lipid-soluble complexes in targeted tumor therapy. J. Nucl. Med. 44, 1293–1300 (2003)
Dewanjee, M.: Cardiac and vascular imaging with labeled platelets and leukocytes. Semin. Nucl. Med. 14, 154–187 (1984)
Virgolini, I., Traub, T., Novotny, C., Leimer, M., Füger, B., Li, S.R., Patri, P., Pangerl, T., Angelberger, P., Raderer, M., Burggasser, G., Andreae, F., Kurtaran, A., Dudczak, R.: Experience with indium-Ill and yttrium-90-labeled somatostatin analogs. Curr. Pharm. Des. 8, 1781–1807 (2002)
Cheson, B.: The role of radioimmunotherapy with yttrium-90 ibritumomab tiuxetan in the treatment of non-Hodgkin lymphoma. BioDrugs 19, 309–322 (2005)
Hafeli, D., Yu, J., Farudi, F., Li, Y., Tapolsky, G.: Radiolabeling of magnetic targeted carriers (MTC) with indium-111. Nucl. Med. BioI. 30, 761–769 (2003)
Silva, A., Silva, E., Carrico, A., Egito, E.: Magnetic carriers: a promising device for targeting drugs into the human body. Curr. Pharm. Des. 13, 1179–1185 (2007)
Abdullin, I., Mironov, M., Garipova, G.: Bactericidal and biologically stable coatings for medical implants and instruments. Med. Tekh. 4, 20–22 (2004)
Taylor, D., Lehmann, M., Planas-Bohne, F., Seidel, A.: The metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies. Radiat. Res. 95, 339–358 (1983)
Ballatori, N.: Molecular mechanisms on hepatic metal transport. In: Zalups, R.J., Koropatnik, J. (eds.) Molecular Biology and Toxicology of Metals, pp. 346–381. CRC Press, New York (2000)
Overall, C., Kleifeld, O.: Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat. Cancer Rev. 6, 227–239 (2006)
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Chain, C.Y., Ceolin, M., Pasquevich, A.F. (2008). PAC research in biology. In: Pasquevich, A., Rentería, M., Saitovitch, E.B., Petrilli, H. (eds) HFI/NQI 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85320-6_96
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DOI: https://doi.org/10.1007/978-3-540-85320-6_96
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