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Chemokines and ischemic stroke

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Inflammation and Stroke

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Chemokines (chemoattractant cytokines) play a vital role in the development and function of the immune system. In addition to this well characterized role, recent evidence has suggested chemokines may be produced by both neurons and glial cells in response to various stimuli, thus implicating chemokines in a number of neurological disorders, including ischemic stroke, trauma, Alzheimer’s disease, multiple sclerosis and brain tumors.

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References

  1. Rollins BJ (1997) Chemokines. Blood 90: 909–928

    PubMed  CAS  Google Scholar 

  2. Luster AD (1998) Chemokines — chemotactic cytokines that mediate inflammation. N Eng J Med 338: 436–445

    Article  CAS  Google Scholar 

  3. Mennicken F, Maki R, De Souza EB, Quirion R (1999) Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning. Trends Pharmacol Sci 20: 73–78

    Article  PubMed  CAS  Google Scholar 

  4. Wells TNC, Power CA, Proudfoot AEI (1998) Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 19: 376–380

    Article  PubMed  CAS  Google Scholar 

  5. Premack BA, Schall TJ (1996) Chemokine receptors: gateways to inflammation and infection. Nat Med 2:1174–1178

    Article  PubMed  CAS  Google Scholar 

  6. Murphy PM (1994) The molecular biology of leukocyte chemotactic receptors. Ann Rev Immunol 12: 593–633

    Article  CAS  Google Scholar 

  7. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Duagherty BL, Gould SL, Springer MS, DeMartino JA (1998) Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem 273: 18288–18291

    Article  PubMed  CAS  Google Scholar 

  8. He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W et al (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385: 645–649

    Article  PubMed  CAS  Google Scholar 

  9. Tanabe S, Heesen M, Berman MA, Fischer MB, Yoshizawa I, Luo Y, Dorf ME (1997) Murine astrocytes express a functional chemokine receptor. J Neurosci 17: 6522–6528

    PubMed  CAS  Google Scholar 

  10. Bacon KB, Harrison JK (2000) Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis. J Neuroimmunol 104: 92–97

    Article  PubMed  CAS  Google Scholar 

  11. Zhang W, Smith C, Shapiro A, Monette R, Hutchison J, Stanimirovic D (1999) Increased expression of bioactive chemokines in human cerebrovascular endothelial cells and astrocytes subjected to ischemia in vitro. J Neuroimmunol 101: 148–160

    Article  PubMed  CAS  Google Scholar 

  12. Liu T, Young PR, McDonnell PC, White RF, Barone FC, Feuerstein GZ (1993) Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia. Neurosci Lett 164: 125–128

    Article  PubMed  CAS  Google Scholar 

  13. Yamasaki Y, Matsuo Y, Matsuura N, Onodera H, Itoyama Y, Kogure K (1995) Transient increase of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, in ischemic brain areas after focal ischemia in rats. Stroke 26: 318–322

    Article  PubMed  CAS  Google Scholar 

  14. Baggiolini M, Dewald B, Moser B (1994) Interleukin-8 and related chemotactic cytokines — CXC and CC chemokines. Adv Immunol 55: 97–179

    Article  PubMed  CAS  Google Scholar 

  15. Yamasaki Y, Matsuo Y, Zagorski J, Matsuura N, Onodera H, Itoyama Y, Kogure K (1997) New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats. Brain Res 759: 103–111

    Article  PubMed  CAS  Google Scholar 

  16. Kostulas N, Kivisakk P, Huang Y, Matusevicious D, Kostulas V, Link H (1998) Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA. Stroke 29: 462–466

    Article  PubMed  CAS  Google Scholar 

  17. Matsumoto T, Ikeda K, Mukaida N, Harada A, Matsumoto Y, Yamashita J, Matsushima K (1997) Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8. Lab Invest 77: 119–125

    PubMed  CAS  Google Scholar 

  18. Kossmann T, Stahel PF, Lenzlinger PM, Redl H, Dubs RW, Trentz O, Schlag G, Morganti-Kossmann MC (1997) Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production. J Cereb Blood Flow Metab 17: 280–289

    Article  PubMed  CAS  Google Scholar 

  19. Wang X, Ellison JA, Siren AL, Lysko PG, Yue TL, Barone FC, Shatzman A, Feuerstein GZ (1998) Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat. J Neurochem 71: 1194–1204

    Article  PubMed  CAS  Google Scholar 

  20. Wang X, Li X, Schmidt DB, Foley JJ, Barone FC, Ames RS, Sarau HM (2000) Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Mol Pharmacol 57: 1190–1198

    PubMed  CAS  Google Scholar 

  21. Wang X, Yue TL, Barone FC, Feuerstein GZ (1995) Monocyte chemoattractant protein-1 messenger RNA expression in rat ischemic cortex. Stroke 26: 661–665

    Article  PubMed  CAS  Google Scholar 

  22. Yamagami S, Tamura M, Hayashi M, Endo N, Tanabe H, Katsuura Y, Komoriya K (1999) Differential production of MCP-1 and cytokine-induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats. J Leukoc Biol 65: 744–749

    PubMed  CAS  Google Scholar 

  23. Gourmala NG, Buttini M, Limonta S, Sauter A, Boddeke HW (1997) Differential and time dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lippopolysaccharide administration. J Neuroimmunol 74: 35–44

    Article  PubMed  CAS  Google Scholar 

  24. Wang X, Li X, Yaish-Ohad S, Sarau HM, Barone FC, Feuerstein, GZ (1999) Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: a possible role in stroke. Brain Res Mol Brain Res 71: 304–312

    Article  PubMed  CAS  Google Scholar 

  25. Gourmala NG, Limonta S, Bochelen D, Sauter A, Boddeke HW (1999) Localization of macrophage inflammatory protein: macrophage inflammatory protein-1 expression in rat brain after peripheral administration of lipopolysaccharide and focal cerebral ischemia. Neuroscience 88: 1255–1266

    Article  PubMed  CAS  Google Scholar 

  26. Takami S, Nishikawa H, Minami M, Nishiyori A, Sato M, Satoh M (1997) Induction of macrophage inflammatory protein MIP-1alpha mRNA on glial cells after focal cerebral ischemia in the rat. Neurosci Lett 227: 173–176

    Article  PubMed  CAS  Google Scholar 

  27. Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJLM (2000) Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitoxic brain damage. J Neurosci 20: RC87 (1–5)

    Google Scholar 

  28. Harrison JK, Jiang Y, Chen SZ, Xia YY, Maciejewski D, Botti P, McNamara RK, Streit WJ, Salafranca MN, Adhikari S et al (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 95: 10896–10901

    Article  PubMed  CAS  Google Scholar 

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© 2001 Springer Basel AG

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Peters, E.E., Feuerstein, G.Z. (2001). Chemokines and ischemic stroke. In: Feuerstein, G.Z. (eds) Inflammation and Stroke. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8297-2_12

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  • DOI: https://doi.org/10.1007/978-3-0348-8297-2_12

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9508-8

  • Online ISBN: 978-3-0348-8297-2

  • eBook Packages: Springer Book Archive

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