Skip to main content

Mechanisms of Combined IL-1/IL-2 and IL-1/IFN Therapy in Mice Injected with Metastatic Tumor Cells

  • Chapter
Combination Therapies

Abstract

Several studies have recently shown that the combined treatment of tumor-bearing animals with multiple cytokines results in a more potent antitumor effect than single cytokine therapy (1–9).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. Silagi, R. Dutkowski, and A. Schaefer, Eradication of mouse melanoma by combined treatment with recombinant human interleukin 2 and recombinant murine interferon-gamma, Int. J. Cancer., 41:315 (1988).

    Article  PubMed  CAS  Google Scholar 

  2. J. K. McIntosh, J. J. Mulé, M. J. Merino, and S. A. Rosenberg, Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha, Cancer Res., 48:4011 (1988).

    PubMed  CAS  Google Scholar 

  3. M. J. Brunda, D. Bellantoni, and V. Sulich, In vivo anti-tumor activity of combinations of interferon alpha and interleukin-2 in a murine model. Correlation of efficacy with the induction of cytotoxic cells resembling natural killer cells, Int. J. Cancer., 40:365 (1987).

    Article  PubMed  CAS  Google Scholar 

  4. J. L. Winkelhake, S. Stampfl, and R. J. Zimmerman, Synergistic effects of combination therapy with human recombinant interleukin-2 and tumor necrosis factor in murine tumor models, Cancer Res., 47:3948 (1987).

    PubMed  CAS  Google Scholar 

  5. J. K. McIntosh, J. J. Mulè, J. A. Krosnick, and S. A. Rosenberg, Combination cytokine immunotherapy with tumor necrosis factor alpha, interleukin 2, and alpha-interferon and its synergistic antitumor effects in mice, Cancer Res., 49:1408 (1989).

    PubMed  CAS  Google Scholar 

  6. M. Iigo, M. Sakurai, T. Tamura, N. Saijo, and A. Hoshi, In vivo antitumor activity of multiple injections of recombinant interleukin 2, alone and in combination with three different types of recombinant interferon on various syngeneic murine tumors, Cancer Res., 48:260 (1988).

    PubMed  CAS  Google Scholar 

  7. S. A. Rosenberg, S. L. Schwarz, and P. J. Spiess, Combination immunotherapy for cancer: synergistic antitumor interactions of interleukin-2, alpha interferon, and tumor-infiltrating lymphocytes, J. Natl. Cancer Inst., 80:1393 (1988).

    Article  PubMed  CAS  Google Scholar 

  8. F. Belardelli, V. Ciolli, U. Testa, E. Montesoro, D. Bulgarini, E. Proietti, P. Borghi, P. Sestili, C. Locardi, C. Peschle, and I. Gresser, Antitumor effects of interleukin-2 and interleukin-1 in mice transplanted with different syngeneic tumors, Int. J. Cancer, 44:1108 (1989).

    Article  PubMed  CAS  Google Scholar 

  9. V. Ciolli, L. Gabriele, P. Sestili, F. Varano, E. Proietti, I. Gresser, U. Testa, E. Montesoro, D. Bulgarini, G. Mariani, C. Peschle, F. Belardelli, Host antitumor mechanisms in the combined IL-1/IL-2 therapy in mice injected with highly metastatic Friend leukemia cells. Effects on established metastases, J. Exp. Med., 173:313 (1991).

    Article  PubMed  CAS  Google Scholar 

  10. F. Belardelli, I. Gresser, C. Maury, and M. T. Maunoury, Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. I, Int. J. Cancer., 30:813 (1982).

    Article  PubMed  CAS  Google Scholar 

  11. F. Belardelli, I. Gresser, C. Maury, P. Duvillard, M. Prade, and M. T. Maunoury, Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously, Int. J. Cancer, 31:649 (1983).

    Article  PubMed  CAS  Google Scholar 

  12. I. Gresser, C. Maury, D. Woodrow, J. Moss, M. G. Grutter, F. Vignaux, F. Belardelli, and M. T. Maunoury, Interferon treatment markedly inhibits the development of tumor metastases in the liver and spleen and increases survival time of mice after intravenous inoculation of Friend erythroleukemia cells, Int. J. Cancer, 41:135 (1988).

    Article  PubMed  CAS  Google Scholar 

  13. I. Gresser, F. Belardelli, J. Tavernier, W. Fiers, F. Podo, M. Federico, G. Carpinelli, P. Duvillard, M. Prade, C. Maury, M. T. Bandu, and M. T. Maunoury, Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. V. Comparison with the action of tumor necrosis factor, Int. J. Cancer, 38:771 (1986).

    Article  PubMed  CAS  Google Scholar 

  14. E. Proietti, F. Belardelli, G. Carpinelli, M. Di Vito, D. Woodrow, J. Moss, P. Sestili, W. Fiers, I. Gresser, and F. Podo, Tumor necrosis factor alpha induces early morphologic and metabolic alterations in Friend leukemia cell tumors and fibrosarcomas in mice, Int. J. Cancer, 42:582 (1988).

    Article  PubMed  CAS  Google Scholar 

  15. F. Belardelli, E. Proietti, V. Ciolli, P. Sestili, G. Carpinelli, M. Di Vito, A. Ferretti, D. Woodrow, D. Boraschi, and F. Podo, Interleukin-lβ induces tumor necrosis and early morphologic and metabolic changes in transplantable mouse tumors. Similarities with the antitumor effects of tumor necrosis factor α or β, Int. J. Cancer, 44:116 (1989).

    Article  PubMed  CAS  Google Scholar 

  16. E. Affabris, C. Jemma, and G.B. Rossi, Isolation of interferon-resistant variants of Friend erythroleukemia cells: effect of interferon and ouabain, Virology, 120:441 (1982).

    Article  PubMed  CAS  Google Scholar 

  17. F. Belardelli, M. Ferrantini, C. Maury, L. Santurbano, and I. Gresser, On the biologic and biochemical differences between in vitro and in vivo passaged Friend Erythroleukemia Cells I. Tumorigenicity and capacity to metastasize, Int. J. Cancer, 34:389 (1984).

    Article  PubMed  CAS  Google Scholar 

  18. K. Bosslet and V. Schirrmacher, High-frequency generation of new immunoresistant tumor variants during metastasis of a cloned murine tumor line (ESb), Int. J. Cancer, 29:195 (1982).

    Article  PubMed  CAS  Google Scholar 

  19. M. G. Tovey, J. Begon-Lours, I. Gresser, A method for the large-scale production of potent interferon preparations, Proc. Soc. Exp. Biol. Med., 146:809 (1974).

    PubMed  CAS  Google Scholar 

  20. I. Gresser, C. Maury, C. Carnaud, E. De Maeyer, M. T.Maunoury, and F. Belardelli, Antitumor effects of Interferon in mice injected with Interferon-sensitive and Interferon-resistant Friend Erythroleukemia Cells. VIII. Role of the immune system in the inhibition of visceral metastases, Int. J. Cancer, 46:468 (1990).

    Article  PubMed  CAS  Google Scholar 

  21. P. G. Braunschweiger, C.S. Johnson, N. Kumar, V. Ord, and P. Furmanski, Antitumor effects of recombinant human interleukin 10 in RIF-1 and Panc02 solid tumors, Cancer Res., 48:6011 (1988).

    PubMed  CAS  Google Scholar 

  22. S. Nakamura, K. Nakata, S. Kashimoto, H. Yoshida, and M. Yamada, Antitumor effect of recombinant human interleukin 1 alpha against murine syngeneic tumors, Jpn. J. Cancer Res. (Gann), 77:767 (1986).

    CAS  Google Scholar 

  23. R. J. North, R.H. Neubauer, J.J.H. Huang, R.C. Newton, and S.E. Loveless, Interleukin 1-induced, T cell-mediated regression of immunogenic murine tumors. Requirement for an adequate level of already acquired host concomitant immunity, J. Exp. Med., 168:2031 (1988).

    Article  PubMed  CAS  Google Scholar 

  24. M. A. Palladino, M. R. Shalaby, S. M. Kramer, B. L. Ferraiolo, R. A. Baughman, A. B. Deleo, D. Crase, B. Marafino, B. B. Aggarwal, I. S. Figari, D. Liggitt, and J. S. Patton, Characterization of the antitumor activities of human tumor necrosis factor-a and the comparison with other cytokines: induction of tumor specific immunity, J. Immunol., 138:4023 (1987).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Belardelli, F., Gabriele, L., Proietti, E., Testa, U., Peschle, C., Gresser, I. (1992). Mechanisms of Combined IL-1/IL-2 and IL-1/IFN Therapy in Mice Injected with Metastatic Tumor Cells. In: Goldstein, A.L., Garaci, E. (eds) Combination Therapies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3340-5_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3340-5_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6472-6

  • Online ISBN: 978-1-4615-3340-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics