Skip to main content
SpringerLink
Log in

Gene Expression in Familial Breast Cancer: A Genetic-Epidemiologic Study of Premenopausal Bilateral Breast Cancer

  • Conference paper
Hormonal Carcinogenesis II

  • 61 Accesses

Abstract

The objectives of our study are to identify and characterize genes involved in the etiology of breast cancer, to define sources of heterogeneity, and to identify factors that may affect expression of inherited susceptibility genes (i.e., gene-gene and gene-environment interactions).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cortessis V, Ingles S, Millikan R, et al. (1993) Linkage Analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer. Cancer Res 53:5083–5086.

    PubMed  CAS  Google Scholar 

  2. Cortessis V, Ingles S, Millikan R et al (1995) A linkage analysis of MFD188 in 66 families with premenopausal bilateral breast cancer, with a focus on heterogeneity. Submitted.

    Google Scholar 

  3. Millikan RC, Ingles S, Diep A, et al., (1995) Linkage analysis of chromosome IP using 66 multiple case breast cancer pedigrees. Submitted.

    Google Scholar 

  4. Ingles S, Millikan RC, Slamon D, et al., (1995) Descriptive epidemiology of HER-2 and p53 overexpression in bilateral breast cancer prevalence, concordance, and associations with BRCA1 and reproductive factors. Submitted.

    Google Scholar 

  5. Slamon DJ, Godolphin W, Jones LA et al (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244:707–712.

    Article  PubMed  CAS  Google Scholar 

  6. Lange K, Boehnke M, Weeks D (1988) Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE. Genetic Epidem 5:471–472.

    Article  CAS  Google Scholar 

  7. Claus E, Risch N, Thompson WD (1991) Genetic analysis of br east cancer in the Cancer and Steroid Hormone Study. Am J Hum Genet 48:232–242.

    PubMed  CAS  Google Scholar 

  8. Page D, Anderson T (1987) Diagnostic histopathology of the breast. New York: Churchill Livingston.

    Google Scholar 

  9. Ott J (1983) Linkage analysis and family classification under heterogeneity. Ann Hum Genet 47:311–320.

    Article  PubMed  CAS  Google Scholar 

  10. Ingles S, Diep A, Haile RW (1995) A logistic random-effects model for gene-environment interaction under linkage heterogeneity: Application to early-onset bilateral breast cancer data. Submitted.

    Google Scholar 

Download references

Authors
  1. Robert W. Haile
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sue Ingles
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Victoria K. Cortessis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert C. Millikan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anh Diep
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Robert S. Sparkes
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) (Professor of Pharmacology, Toxicology, and Therapeutics, Director)

  2. Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  3. Department of Medical Nutrition, Center for Biotechnology, NOVUM, Huddinge University Hospital, Huddinge, Sweden

    Jan-Åke Gustafsson M.D., Ph.D. (Professor and Chairman, Director) (Professor and Chairman, Director)

  4. Department of Molecular and Cell Biology, Cancer Research Center, University of California, Berkeley, California, USA

    Satyabrata Nandi Ph.D. (Professor of Cell and Development Biology) (Professor of Cell and Development Biology)

  5. Division of Cancer Etiology, Chemical and Physical Carcinogenesis Program, National Cancer Institute, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

  6. University of Kansas Medical Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) & Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Professor of Pharmacology, Toxicology, and Therapeutics, Director) &  (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  7. National Institutes of Health, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag New York, Inc.

About this paper

Cite this paper

Haile, R.W., Ingles, S., Cortessis, V.K., Millikan, R.C., Diep, A., Sparkes, R.S. (1996). Gene Expression in Familial Breast Cancer: A Genetic-Epidemiologic Study of Premenopausal Bilateral Breast Cancer. In: Li, J.J., Li, S.A., Gustafsson, JÅ., Nandi, S., Sekely, L.I. (eds) Hormonal Carcinogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2332-0_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2332-0_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7506-0

  • Online ISBN: 978-1-4612-2332-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation