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Stem Cells and Tissue Engineering

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

Part of the book series: Methods in Bioengineering ((MB))

Abstract

Every year millions of people suffer tissue loss or end-stage organ failure (Langer and Vacanti 1993). Total national US health care costs for these patients exceed 400 billion dollars per year. Currently over 8 million surgical procedures requiring 40 to 90 million hospital days are performed annually in the United States to treat these disorders. Options such as tissue transplantation and surgical intervention are severely limited by critical donor shortages, long-term morbidity, and mortality. Stem cells could be used as a source of donor tissue in transplants and elective surgeries. They could also be used in the treatment of a wide variety of diseases, congenital malformations, and genetic disorders. One especially appropriate application for stem cells involves the treatment of tissue losses, which requires that large numbers of cells be available for transplantation. Similar issues arise with respect to providing sufficient numbers of cells for gene therapy.

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Authors
  1. Henry E. Young
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Editors and Affiliations

  1. Growth and Development Laboratory Department of Orthopaedic Surgery and Molecular Genetics and Biochemistry, Chilren’s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, PA, 15213-2583, USA

    Johnny Huard

  2. Department of Orthopaedic Surgery Musculoskeletal Research Center Center for Sports Medicine, University of Pittsburgh, Pittsburgh, PA, 15213-2583, USA

    Freddie H. Fu

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© 2000 Birkhäuser Boston

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Young, H.E. (2000). Stem Cells and Tissue Engineering. In: Huard, J., Fu, F.H. (eds) Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine. Methods in Bioengineering. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-2126-5_9

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  • DOI: https://doi.org/10.1007/978-1-4612-2126-5_9

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-7424-7

  • Online ISBN: 978-1-4612-2126-5

  • eBook Packages: Springer Book Archive

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