As of September 2, 2007 when this chapter was written, there were an estimated 994,638 words in the English language (http://www.languagemonitor.com/). Everyone agrees that we are not born with the knowledge of these words and the rules by which they are strung together. A newborn child does not know or use any words. However, a child entering school has a lexicon of ~ 13,000 words which, by the end of schooling, expands to ~ 60,000 words and during adulthood reaches ~ 120,000 words (Pinker 1999).
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References
Alcock, K. J., Passingham, R. E., Watkins, K. E., & Vargha-Khadem, F. (2000a). Oral dyspraxia in inherited speech and language impairment and acquired dysphasia. Brain & Language, 75, 17–33.
Alcock, K. J., Passingham, R. E., Watkins, K. E., & Vargha-Khadem, F. (2000b). Pitch and timing abilities in inherited speech and language impairment. Brain & Language, 75, 34–46.
Ambrose, N., Yairi, E., & Cox, N. J. (1993). Genetic aspects of early childhood stuttering. Journal of Speech & Hearing Research, 36, 701–706.
Ardila, A., Bateman, J. R., Nino, C. R., Pulido, E., Rivera, D. B., & Vanegas, C. J. (1994). An epidemiologic study of stuttering. Journal of Communication Disorders, 27, 37–48.
Barry, J. G., Yasin, I., & Bishop, D. V. (2006). Heritable risk factors associated with language impairments. Genes, Brain & Behavior, 6, 66–76.
Bartlett, C. W., Flax, J. F., Logue, M. W., Smith, B. J., Vieland, V. J., Tallal, P., et al. (2004). Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Human Heredity, 57, 10–20.
Bartlett, C. W., Flax, J. F., Logue, M. W., Vieland, V. J., Bassett, A. S., Tallal, P., et al. (2002). A major susceptibility locus for specific language impairment is located on 13q21. American Journal of Human Genetics, 71, 45–55.
Bates, E. A. (2004). Explaining and interpreting deficits in language development across clinical groups: where do we go from here? Brain & Language, 88, 248–253.
Belton, E., Salmond, C. H., Watkins, K. E., Vargha-Khadem, F., & Gadian, D. G. (2003). Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia. Human Brain Mapping, 18, 194–200.
Bishop, D. V. (1994a). Grammatical errors in specific language impairment: Competence or performance limitations? Applied Psycholinguistics, 15, 507–550.
Bishop, D. V. (1994b). Is specific language impairment a valid diagnostic category? Genetic and psycholinguistic evidence. Philosophical Transactions of the Royal Society of London – Series B: Biological Sciences, 346, 105–111.
Bishop, D. V. (2005). Developmental cognitive genetics: how psychology can inform genetics and vice versa. Quarterly Journal of Experimental Psychology, 59, 1153–1168.
Bishop, D. V., Adams, C. V., & Norbury, C. F. (2006). Distinct genetic influences on grammar and phonological short-term memory deficits: Evidence from 6-year-old twins. Genes, Brain & Behavior, 5, 158–169.
Bishop, D. V., & Edmundson, A. (1986). Is otitis media a major cause of specific developmental language disorders? British Journal of Disorders of Communication, 21, 321–338.
Bishop, D. V., Laws, G., Adams, C., & Norbury, C. F. (2006). High heritability of speech and language impairments in 6-year-old twins demonstrated using parent and teacher report. Behavior Genetics, 36, 173–184.
Bishop, D. V., North, T., & Donlan, C. (1995). Genetic basis of specific language impairment: evidence from a twin study. Developmental Medicine & Child Neurology, 37, 56–71.
Bishop, D. V., North, T., & Donlan, C. (1996). Nonword repetition as a behavioural marker for inherited language impairment: evidence from a twin study. Journal of Child Psychology & Psychiatry & Allied Disciplines, 37, 391–403.
Bloodstein, O. (1995). A handbook on stuttering. Chicago, IL: National Easter Seal Society.
Choudhury, N., & Benasich, A. A. (2003). A family aggregation study: the influence of family history and other risk factors on language development. Journal of Speech Language & Hearing Research, 46, 261–272.
Cleave, P. L., & Rice, M. L. (1997). An examination of the morpheme BE in children with specific language impairment: the role of contractibility and grammatical form class. Journal of Speech Language & Hearing Research, 40, 480–492.
Cole, K. N., Schwartz, I. S., Notari, A. R., Dale, P. S., & Mills, P. E. (1995). Examination of the stability of two methods of defining specific language impairment. Applied Psycholinguistics, 16, 103–123.
Coltheart, M., Curtis, B., Atkins, P., & Haller, M. (1993). Models of reading aloud: Dual-route and parallel-distributed-processing approaches. Psychological Review, 100, 589–608.
Coltheart, M., Rastle, K., Perry, C., Langdon, R., & Ziegler, J. (2001). DRC: A dual route cascaded model of visual word recognition and reading aloud. Psychological Review, 108, 204–256.
Cox, N. J., Kramer, P., & Kidd, K. (1984). Segregation analyses of stuttering. Genetic Epidemiology, 1, 245–253.
DeThorne, L. S., Hart, S. A., Petrill, S. A., Deater-Deckard, K., Thompson, L. A., Schatschneider, C., et al. (2006). Children’s history of speech-language difficulties: genetic influences and associations with reading-related measures. Journal of Speech Language & Hearing Research, 49, 1280–1293.
Felsenfeld, S. (2002). Finding susceptibility genes for developmental disorders of speech: the long and winding road. Journal of Communication Disorders, 35, 329–345.
Felsenfeld, S., Kirk, K., Zhu, G., Statham, M., Neale, M., & Martin, N. (2000). A study of the genetic and environmental etiology of stuttering in a selected twin sample. Behavior Genetics, 30, 359–366.
Felsenfeld, S., & Plomin, R. (1997). Epidemiological and offspring analyses of developmental speech disorders using data from the Colorado Adoption Project. Journal of Speech, Language and Hearing Research, 41, 778–791.
Fisher, S. E., Lai, C. S., & Monaco, A. P. (2003). Deciphering the genetic basis of speech and language disorders. Annual Review of Neuroscience, 26, 57–80.
Fisher, S. E., Vargha-Khadem, F., Watkins, K. E., Monaco, A. P., & Pembrey, M. E. (1998). Localisation of a gene implicated in a severe speech and language disorder. Nature Genetics, 18, 168–170.
French, C. A., Groszer, M., Preece, C., Coupe, A. M., Rajewsky, K., & Fisher, S. E. (2007). Generation of mice with a conditional Foxp2 null allele. Genesis: the Journal of Genetics & Development, 45, 440–446.
Gopnik, M., & Crago, M. B. (1991). Familial aggregation of a developmental language disorder. Cognition, 39, 1–50.
Gopnik, M., & Goad, H. (1997). What underlies inflectional error patterns in genetic dysphasia? Journal of Neurolinguistics, 10, 109–137.
Grigorenko, E. L. (in press). Speaking genes or genes for speaking? Deciphering the genetics of speech and language. Journal of Child Psychology and Psychiatry.
Haines, J., & Camarata, S. (2004). Examination of candidate genes in language disorder: a model of genetic association for treatment studies. Mental Retardation & Developmental Disabilities Research Reviews, 10, 208–217.
Haskell, T. R., MacDonald, M. C., & Seidenberg, M. S. (2003). Language learning and innateness: Some implications of Compounds Research. Cognitive Psychology, 47, 119–163.
Howie, P. M. (1981). Concordance for stuttering in monozygotic and dizygotic twin pairs. Journal of Speech & Hearing Research, 24, 317–321.
Hurst, J. A., Baraitser, M., Auger, E., Graham, F., & Norell, S. (1990). An extended family with a dominantly inherited speech disorder. Developmental Medicine and Child Neurology, 32, 352–355.
Joanisse, M. F. (2004). Specific Language Impairments in children phonology, semantics, and the English past tense. Current Directions in Psychological Science, 13, 156–160.
Kaufmann, E., & Knöchel, W. (1996). Five years on the wings of fork head. Mechanisms of Development, 57, 3–20.
Kidd, K. K. (1984). Stuttering as a genetic disorder. In R. Curlee & W. Perkins (Eds.), Nature and treatment of stuttering (pp. 149–169). San Diego, CA: College Hill.
Grigorenko, E. L. (in press). Speaking genes or genes for speaking? Deciphering the genetics of speech and language. Journal of Child Psychology and Psychiatry.
Kidd, K. K., Heimbuch, R. C., Records, M. A., Oehlert, G., & Webster, R. L. (1980). Familial stuttering patterns are not related to one measure of severity. Journal of Speech & Hearing Research, 23, 539–545.
Kovas, Y., Hayiou-Thomas, M. E., Oliver, B., Dale, P. S., Bishop, D. V., & Plomin, R. (2005). Genetic influences in different aspects of language development: The etiology of language skills in 4.5-year-old twins. Child Development, 76, 632–651.
Lahey, M., & Edwards, J. (1995). Specific language impairment: Preliminary investigation of factors associated with family history and with patterns of language performance. Journal of Speech and Hearing Research, 38, 643–657.
Lai, C. S., Fisher, S. E., Hurst, J. A., Levy, E. R., Hodgson, S., Fox, M., et al. (2000). The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. American Journal of Human Genetics, 67, 357–368.
Lai, C. S., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F., & Monaco, A. P. (2001). A forkhead-domain gene is mutated in a severe speech and language disorder. Nature, 413, 519–523.
Leonard, L. B. (1998). Children with specific language impairment. Cambridge, MA: MIT Press.
Levis, B., Ricci, D., Lukong, J., & Drayna, D. (2004). Genetic linkage studies in a large West African kindred. American Journal of Human Genetics, 75, S2026.
Lewis, B. A., Cox, N. J., & Byard, P. J. (1993). Segregation analysis of speech and language disorders. Behavior Genetics, 23, 291–297.
Lewis, B. A., Ekelman, B. L., & Aram, D. M. (1989). A familial study of severe phonological disorders. Journal of Speech and Hearing Research, 32, 713–724.
Lewis, B. A., & Thompson, L. A. (1992). A study of developmental speech and language disorders in twins. Journal of Speech and Hearing Research, 35, 1086–1094.
Liègeois, F., Baldeweg, T., Connelly, A., Gadian, D. G., Mishkin, M., & Vargha-Khadem, F. (2003). Language fMRI abnormalities associated with FOXP2 gene mutation. Nature Neuroscience, 6, 1230–1237.
MacDermot, K. D., Bonora, E., Sykes, N., Coupe, A. M., Lai, C. S., Vernes, S. C., et al. (2005). Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. American Journal of Human Genetics, 76, 1074–1080.
Marshall, C. R., & van der Lely, H. K. (2006). A challenge to current models of past tense inflection: the impact of phonotactics. Cognition, 100, 302–320.
McClelland, J. L., & Patterson, K. (2002). Rules or connections in past-tense inflections: What does the evidence rule out? Trends in Cognitive Sciences, 6, 465–472.
Meaburn, E., Dale, P. S., Craig, I. W., & Plomin, R. (2002). Language-impaired children: No sign of the FOXP2 mutation. Cognitive Neuroscience and Neuropsychology, 13, 1075–1077.
Miscimarra, L. E., Stein, C. M., Millard, C., Kluge, A., Cartier, K. C., Freebairn, L. A., et al. (2007). Further evidence of pleiotropy influencing speech and language: Analysis of the DYX8 region. Human Heredity, 63, 47–58.
Neils, J., & Aram, D. M. (1986). Family history of children with developmental language disorders. Perceptual Motor Skills, 63, 655–658.
Newbury, D. F., Bonora, E., Lamb, J. A., Fisher, S. E., Lai, C. S. L., Baird, G., et al. (2002). FOXP2 is not a major susceptibility gene for autism or specific language impairment. American Journal of Human Genetics, 70, 1318–1327.
O’Brien, E. K., Zhang, X., Nishimura, C., Tomblin, J. B., & Murray, J. C. (2003). Association of Specific Language Impairment (SLI) to the region of 7q31. American Journal of Human Genetics, 72, 1536–1543.
Pinker, S. (1991). Rules of language. In P. Bloom (Ed.), Language acquisition: Core readings. New York, NY: Harvester Wheatsheaf.
Pinker, S. (1999). Words and rules: The ingredients of language. New York, NY, US: Basic Books.
Pinker, S., & Ullman, M. T. (2002). The past and future of the past tense. Trends in Cognitive Sciences, 6, 456–463.
Plaut, D. C. (1996). Relearning after damage in connectionist networks: Toward a theory of rehabilitation. Brain and Language, 52, 25–82.
Redmond, S. M., & Rice, M. L. (2001). Detection of irregular verb violations by children with and without SLI. Journal of Speech Language & Hearing Research, 44, 655–669.
Riaz, N., Steinberg, S., Ahmad, J., Pluzhnikov, A., Riazuddin, S., Cox, N. J., et al. (2005). Genomewide significant linkage to stuttering on chromosome 12. American Journal of Human Genetics, 76, 647–651.
Rice, M. L., Cleave, P. L., & Oetting, J. B. (2000). The use of syntactic cues in lexical acquisition by children with SLI. Journal of Speech Language & Hearing Research, 43, 582–594.
Rice, M. L., Haney, K. R., & Wexler, K. (1998). Family histories of children with SLI who show extended optional infinitives. Journal of Speech Language & Hearing Research, 41, 419–432.
Rice, M. L., Tomblin, J. B., Hoffman, L., Richman, W. A., & Marquis, J. (2004). Grammatical tense deficits in children with SLI and nonspecific language impairment: relationships with nonverbal IQ over time. Journal of Speech Language & Hearing Research, 47, 816–834.
Rice, M. L., Wexler, K., & Cleave, P. L. (1995). Specific language impairment as a period of extended optional infinitive. Journal of Speech & Hearing Research, 38, 850–863.
Rice, M. L., Wexler, K., Marquis, J., & Hershberger, S. (2000). Acquisition of irregular past tense by children with specific language impairment. Journal of Speech Language & Hearing Research, 43, 1126–1145.
Rice, M. L., Wexler, K., & Redmond, S. M. (1999). Grammaticality judgments of an extended optional infinitive grammar: evidence from English-speaking children with specific language impairment. Journal of Speech Language & Hearing Research, 42, 943–961.
Rumelhart, D. E., & McClelland, J. L. (1987). On learning the past tenses of English verbs. In J. L. McClelland, D. E. Rumelhart, & t. P. R. Group (Eds.), Parallel distributed processing: Explorations in the microstructure of cognition (Vol. 2). Cambridge, MA: MIT Press.
Seidenberg, M. S. (2005). Connectionist models of word reading. Current Directions in Psychological Science, 14, 238–242.
Seidenberg, M. S., & McClelland, J. L. (1989). A distributed, developmental model of word recognition and naming. Psychological Review, 96, 523–568.
Shriberg, L. D. (2002, November 22–24). Classification and misclassification of child speech sound disorders. Paper presented at The Annual Conference of the American Speech-Language-Hearing Association, Atlanta.
Shugart, Y. Y., Mundorff, J., Kilshaw, J., Doheny, K., Doan, B., Wanyee, J., et al. (2004). Results of a genome-wide linkage scan for stuttering. American Journal of Medical Genetics, 124, 133–135.
Smith, S. D. (2007). Genes, language development, and language disorders. Mental Retardation & Developmental Disabilities Research Reviews, 13, 96–105.
Smith, S. D., Pennington, B. F., Boada, R., & Shriberg, L. D. (2005). Linkage of speech sound disorder to reading disability loci. Journal of Child Psychology and Psychiatry, 46, 1057–1066.
Somerville, M. J., Mervis, C. B., Young, E. J., Seo, E. J., del Campo, M., Bamforth, S., et al. (2005). Severe expressive-language delay related to duplication of the Williams-Beuren locus. New England Journal of Medicine, 353, 1694–1701.
Stein, C. M., Millard, C., Kluge, A., Miscimarra, L. E., Cartier, K. C., Freebairn, L. A., et al. (2006). Speech sound disorder influenced by a locus in 15q14 region. Behavior Genetics, 36, 858–868.
Stein, C. M., Schick, J. H., Taylor, G. H., Shriberg, L. D., Millard, C., Kundtz-Kluge, A., et al. (2004). Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. American Journal of Human Genetics, 74, 283–297.
Stromswold, K. (1998). Genetics of spoken language disorders. Human Biology, 70, 297, 291–212.
Stromswold, K. (2001). The heritability of language: A review and meta-analysis of twin, adoption, and linkage studies. Language, 77, 647–723.
Suresh, R., Ambrose, N., Roe, C., Pluzhnikov, A., Wittke-Thompson, J. K., Ng, M. C.-Y., et al. (2006). New complexities in the genetics of stuttering: Significant sex-specific linkage signals. American Journal of Human Genetics, 78, 554–563.
Tager-Flusberg, H., & Joseph, R. M. (2003). Identifying neurocognitive phenotypes in autism. Philosophical Transactions of the Royal Society of London – Series B: Biological Sciences, 358, 303–314.
Tallal, P., Hirsch, L. S., Realpe-Bonilla, T., Miller, S., Brzustowicz, L. M., Bartlett, C. W., et al. (2001). Familial aggregation in Specific Language Impairment. Journal of Speech, Language and Hearing Research, 44, 1172–1182.
Tallal, P., Ross, R., & Curtiss, S. (1989). Familial aggregation in specific language impairment. Journal of Speech and Hearing Disorders, 54, 167–173.
The SLI Consortium. (2002). A genomewide scan identifies two novel loci involved in SLI. American Journal of Human Genetics, 70, 384–398.
The SLI Consortium. (2004). Highly significant linkage to the SLI1 locus in an expanded sample of individuals affected by SLI. American Journal of Human Genetics, 74, 1225–1238.
Tomblin, J. B. (1989). Familial concentration of developmental language impairment. Journal of Speech and Hearing Disorders, 54, 287–295.
Tomblin, J. B., & Buckwalter, P. R. (1998). Heritability of poor language achievement among twins. Journal of Speech and Hearing Research, 41, 188–199.
Tyson, C., McGillivray, B., Chijiwa, C., & Rajcan-Separovic, E. (2004). Elucidation of a cryptic interstitial 7q31.3 deletion in a patient with a language disorder and mild mental retardation by array-CGH. American Journal of Medical Genetics. Part A., 129, 254–260.
Ullman, M. T., Corkin, S., Coppola, M., Hickok, G., Growdon, J. H., Koroshetz, W. J., et al. (1997). A neural dissociation within language: Evidence that the mental dictionary is part of declarative memory, and that grammatical rules are processed by the procedural system. Journal of Cognitive Neuroscience, 9, 266–276.
van der Lely, H. K. (2005). Domain-specific cognitive systems: insight from Grammatical-SLI. Trends in Cognitive Sciences, 9, 53–59.
van der Lely, H. K., Rosen, S., & Adlard, A. (2004). Grammatical language impairment and the specificity of cognitive domains: Relations between auditory and language abilities. Cognition, 94, 167–183.
van der Lely, H. K., & Stollwerck, L. (1996). A grammatical specific language impairment in children: an autosomal dominant inheritance? Brain and Language, 52, 484–504.
van der Lely, H. K., & Stollwerck, L. (1997). Binding theory and grammatical specific language impairment in children. Cognition, 62, 245–290.
Vargha-Khadem, F., Watkins, K., Alcock, K. J., Fletcher, P., & Passingham, R. E. (1995). Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder. Proceedings of the National Academy of Sciences of the United States of America, 92, 930–933.
Vargha-Khadem, F., Watkins, K. E., Price, C. J., Ashburner, J., Alcock, K. J., Connelly, A., et al. (1998). Neural basis of an inherited speech and language disorder. Proceedings of the National Academy of Sciences of the United States of America, 95, 12695–12700.
Verhoeven, L., & van Balkom, H. (Eds.). (2004). Classification of developmental language disorders. Mahwah, NJ: Lawrence Erlbaum.
Vernes, S. C., Newbury, D. F. Abrahsms., B. S., Winchester, L., Nicod, J., Groszer, M., et al. (2008). A functional genetic link between distinct developmental language disorders. The New England Journal of Medicine, 359, 2337–2345.
Viswanath, N., Lee, H. S., & Chakraborty, R. (2004). Evidence for a major gene influence on persistent developmental stuttering. Human Biology, 76, 401–412.
Watkins, K. E., Dronkers, N. F., & Vargha-Khadem, F. (2002). Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia. Brain, 125, 452-464.
Watkins, K. E., Vargha-Khadem, F., Ashburner, J., Passingham, R. E., Connelly, A., Friston, K. J., et al. (2002). MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain, 125, 465–478.
White, S. A., Fisher, S. E., Geschwind, D. H., Scharff, C., & Holy, T. E. (2006). Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language. Journal of Neuroscience, 26, 10376–10379.
Wittke-Thompson, J. K., Ambrose, N., Yairi, E., Roec, C., Cook, E. H., Ober, C., et al. (2007). Genetic studies of stuttering in a founder population. Journal of Fluency Disorders, 32, 33–50.
Yairi, E., & Ambrose, N. G. (1999). Early childhood stuttering I: Persistency and recovery rates. Journal of Speech, Language, and Hearing Research, 42, 1097–1112.
Yairi, E., & Ambrose, N. G. (2005). Early childhood stuttering. Austin, TX: Pro-Ed.
Zevin, J. D., & Seidenberg, M. S. (2006). Simulating consistency effects and individual differences in nonword naming: A comparison of current models. Journal of Memory and Language, 54, 145–160.
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Grigorenko, E.L. (2009). Behavior-Genetic and Molecular Studies of Disorders of Speech and Language: An Overview. In: Kim, YK. (eds) Handbook of Behavior Genetics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76727-7_9
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