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B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1

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Epigenetic Regulation of Lymphocyte Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 356))

Abstract

Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique ‘zinc knuckle’, which mediates a novel mode of DNA recognition. Chromatin immunoprecipitation of EBF1 in pro-B cells defined hundreds of new, as well as previously identified, target genes. Notably, expression of the pre-B cell receptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes.

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Acknowledgments

J.R. was supported by NIH Post-doctoral Training Grant T32 AI07405. J.H. is generously supported by NIH grants R01 AI54661, R01 AI81878 and P01 AI22295.

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  1. Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, Denver, CO, 80206, USA

    James Hagman, Julita Ramírez & Kara Lukin

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Correspondence to James Hagman .

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    Cornelis Murre

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Hagman, J., Ramírez, J., Lukin, K. (2011). B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1. In: Murre, C. (eds) Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology, vol 356. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_139

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