Synonyms
Murine immune system, mouse immune system, rat immune system
Definition
Our understanding of cells and tissues that make up the immune system of vertebrates came from seminal studies of avian species. However, rodents have become the animal model of choice for studies of immunocompetence, and most of our knowledge of the development of the immune system has come from studies using mice or rats. The rodent immune system develops through a set of critical windows of vulnerability during embryonic and adult life that can be used for evaluating effects of environmental exposure to potentially toxic compounds (1). Most of the information in this review comes from studies of mice and, in all cases tested, closely parallels that found in other rodents, including rats.
Characteristics
Embryonic development. Embryonic development of the immune system in rodents initiates with formation of multipotential hematopoietic stem cells(HSC) in intraembryonic spanchnoplure surrounding the...
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References
Dietert RR, Etzel RA, Chen D, Halonen M, Holladay S, Jarabek AM, Landreth K, Pedan D, Pinkerton K, Smialowicz RJ, Zoetis T (2000) Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. Environ Health Perspect 108 [Suppl 3]:483–490
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Landreth KS (2002) Critical windows in development of the rodent immune system. Hum Exp Toxicol 21:493–498
Landreth KS (1993) B lymphocyte development as a developmental process. In: Cooper EL, Nisbet-Brown E (eds) Developmental Immunology. Oxford University Press, New York, pp 238–273
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© 2005 Springer-Verlag
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Landreth, K.S. (2005). Rodent Immune System, Development of the. In: Vohr, HW. (eds) Encyclopedic Reference of Immunotoxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27806-0_1297
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DOI: https://doi.org/10.1007/3-540-27806-0_1297
Publisher Name: Springer, Berlin, Heidelberg
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