2 Result(s)

within Alexandre Vanoosthuyse

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  1. Open Access This content is freely available online to anyone, anywhere at any time.

    Article

    Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

    Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregatio...

    Peng Wang, Gerard Joberty, Arjan Buist, Alexandre Vanoosthuyse in Acta Neuropathologica (2017)

  2. Open Access This content is freely available online to anyone, anywhere at any time.

    Article

    Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

    Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ) induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in conversion from preclinical ...

    Bruno Vasconcelos, Ilie-Cosmin Stancu, Arjan Buist, Matthew Bird in Acta Neuropathologica (2016)