41,177 Result(s)

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  1. No Access


    Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting

    Targeting angiogenesis is a strategy to better control tumor growth and metastasis. αvβ3 is an integrin, involved in the regulation of angiogenesis and overexpressed in angiogenic endothelial cells and various ca...

    Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui (2016)

  2. No Access


    Scalable Expansion of Human Pluripotent Stem Cell-Derived Neural Progenitors in Stirred Suspension Bioreactor Under Xeno-free Condition

    Recent advances in neural differentiation technology have paved the way to generate clinical grade neural progenitor populations from human pluripotent stem cells. These cells are an excellent source for the p...

    Shiva Nemati, Saeed Abbasalizadeh, Hossein Baharvand Ph.D. (2016)

  3. No Access


    177Lu-Labeled RGD-BBN Peptide for Targeting Prostate Cancer

    Over the past two decades, peptide receptor radionuclide therapy (PRRT) has been developed as a valid approach for cancer adjuvant treatment. 177Lu is an excellent radionuclide suitable for radionuclide therapy o...

    Lei Jiang, Zhen Cheng Ph.D. (2016)

  4. No Access


    Whole-Heart Construct Cultivation Under 3D Mechanical Stimulation of the Left Ventricle

    Today the concept of Whole-Heart Tissue Engineering represents one of the most promising approaches to the challenge of synthesizing functional myocardial tissue. At the current state of scientific and technol...

    Jörn Hülsmann, Hug Aubin, Alexander Wehrmann, Alexander Jenke, Artur Lichtenberg (2016)

  5. No Access


    Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides

    Liposomes containing cytotoxic agents and decorated with Cyclic Arg-Gly-Asp (cRGD) pentapeptides have attracted considerable attention for targeting tumor vasculature. These cRGD peptides have been used for ta...

    Mohamadreza Amin, Mahmoud Reza Jaafari (2016)

  6. No Access


    Integrin α v β 3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide

    Integrin αvβ3 is one of the most important factors during angiogenesis (i.e., the formation of new vasculature). To fully elucidate its role in different pathological process, a tool which can visualize its distr...

    Hao Hong, Weibo Cai (2016)

  7. No Access


    Understanding Water and Its Many Roles in Biological Structure: Ways to Exploit a Resource for Drug Discovery

    The importance of water molecules in biological interactions is not debatable, but the various diverse and specific roles that water can play are not as well understood on a molecular scale. In this methods re...

    Mostafa H. Ahmed, Alessio Amadasi, Alexander S. Bayden, Derek J. Cashman (2016)

  8. No Access


    Computational Fragment-Based Drug Design

    Fragment-based drug design (FBDD) is a promising approach for drug discovery. Experimental FBDD faces some intrinsic limitations and challenges such as the high requirements for the quality of target proteins ...

    Chunquan Sheng, Guoqiang Dong, Chen Wang (2016)

  9. No Access


    Three-Dimensional Electron Microscopy Imaging of Spines in Non-human Primates

    Dendritic spines are the main sites of excitatory glutamatergic synapses in the central nervous system. Morphological, ultrastructura l, and numerical changes in dendritic spines are associated with long-term ...

    R. M. Villalba, J. F. Paré, Y. Smith (2016)

  10. No Access


    Generation of Neural Progenitor Spheres from Human Pluripotent Stem Cells in a Suspension Bioreactor

    Conventional two-dimensional (2-D) culture systems cannot provide large numbers of human pluripotent stem cells (hPSCs) and their derivatives that are demanded for commercial and clinical applications in in vi...

    Yuanwei Yan, Liqing Song, Ang-Chen Tsai, Teng Ma, Yan Li (2016)

  11. No Access


    Histology of Type 1 Diabetes Pancreas

    The islets of Langerhans play a critical role in glucose homeostasis. Islets are predominantly composed of insulin-secreting beta cells and glucagon-secreting alpha cells. In type 1 diabetes, the beta cells ar...

    Abby Willcox, Kathleen M. Gillespie (2016)

  12. No Access


    Methylation Analysis in Distinct Immune Cell Subsets in Type 1 Diabetes

    Epigenetics provides a mechanism in which the environment can interact with the genotype to produce a variety of phenotypes. These epigenetic modifications have been associated with altered gene expression and...

    Mary N. Dang, Claire M. Bradford, Paolo Pozzilli, R. David Leslie (2016)

  13. No Access


    Adoptive Transfer of Autoimmune Diabetes Using Immunodeficient Nonobese Diabetic (NOD) Mice

    Studying Type 1 Diabetes (T1D) in the nonobese diabetic (NOD) mouse model can be cumbersome as onset of disease does not usually occur naturally prior to the age of 12–14 weeks and is often restricted to femal...

    Evy De Leenheer, F. Susan Wong (2016)

  14. No Access


    Tracking Immunological Responses of Islet Antigen-Specific T Cells in the Nonobese Diabetic (NOD) Mouse Model of Type 1 Diabetes

    Tracking autoreactive cells in vivo is important in the study of autoimmune diseases, such as type 1 diabetes. This method provides a model to study the responses of T cells responding to physiologically relev...

    Terri C. Thayer, F. Susan Wong (2016)

  15. No Access


    Detection of Total UDP-Glucuronosyltransferase (UGT) Activity in Melanoma Cells

    The UDP-glucuronosyltransferases (UGTs) are integrally involved in the clearance of a wide range of drugs used to combat human diseases. UGT expression levels and activity can be induced by drug addition to ce...

    Ryan W. Dellinger Ph.D., Frank L. Meyskens Jr. (2016)

  16. No Access


    Expansion of Human Induced Pluripotent Stem Cells in Stirred Suspension Bioreactors

    Human induced pluripotent stem cells (hiPSCs) hold great promise as a cell source for therapeutic applications and regenerative medicine. Traditionally, hiPSCs are expanded in two-dimensional static culture as...

    Walaa Almutawaa, Leili Rohani, Derrick E. Rancourt (2016)

  17. No Access


    Engineering T-Cell Specificity Genetically to Generate Anti-melanoma Reactivity

    Melanoma tumors are known to harbor a high number of mutations leading to the expression of neo-antigens which can be recognized by the patient adaptive immune system. In this regard, immunotherapies involving...

    Eviatar Weizman, Cyrille J. Cohen (2016)

  18. No Access


    Effects of Malignant Melanoma Initiating Cells on T-Cell Activation

    Although human malignant melanoma is a highly immunogenic cancer, both the endogenous antitumor immune response and melanoma immunotherapy often fail to control neoplastic progression. Accordingly, characteriz...

    Tobias Schatton, Ute Schütte, Markus H. Frank (2016)

  19. No Access


    Introduction: Field and In Situ Studies

    Mesocosms and microcosms provide an experimentally tractable way to study environmental processes under close to natural conditions while maintaining some control over gross physical processes. They also allow...

    Roger C. Prince (2016)

  20. No Access


    Electron Microscopy of the Brains of Drosophila Models of Alzheimer’s Diseases

    The fruit fly Drosophila is widely used as a genetic model organism and recently emerged as a powerful system in which to study human diseases. We established fly models of Alzheimer’s disease (AD) by expressing ...

    Kanae Ando, Stephen Hearn, Emiko Suzuki, Akiko Maruko-Otake, Michiko Sekiya (2016)

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