Living Reference Work Entry

Encyclopedia of Lipidomics

pp 1-3

Date: Latest Version

Supercritical Fluid

  • Yoshihiro IzumiAffiliated withDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University
  • , Hiroaki TakedaAffiliated withDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University
  • , Takeshi BambaAffiliated withDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University Email author 

Synonyms

Supercritical fluid chromatography- mass spectrometry of lipids; Supercritical fluid extraction:​ carbon dioxide; Supercritical fluid extraction:​ modifier

Physico-Chemical Properties of Supercritical Fluids

A supercritical fluid (SCF), which is kept beyond its critical point in both temperature and pressure, is defined as a high-density and noncondensable fluid. Figure 1 shows the phase diagram of a pure substance. At the triple point, the three phases (gas, liquid, and solid) of the substance coexist in thermodynamic equilibrium. As the temperature goes high, the substance coexists in two phases (i.e., gas and liquid). At the critical point and in the region the temperature and the pressure are above the critical temperature and pressure, the substance exists in a single gaseous phase. The substance in this region is defined as in the SCF state. Thermophysical properties of a SCF are as follows: (i) intermediate density between a gas and a liquid, (ii) intermediate diffusion coef ...

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