Living Reference Work Entry

Encyclopedia of Lipidomics

pp 1-3

Date: Latest Version

Supercritical Fluid Extraction: Modifier

  • Hiroaki TakedaAffiliated withDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University
  • , Yoshihiro IzumiAffiliated withDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University
  • , Takeshi BambaAffiliated withDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University Email author 

Synonyms

Glycerophosphoch​olines; Glycerophosphoet​hanolamines; Glycerophospholi​pids; Liquid Extraction:​ acidic extraction; Liquid Extraction:​ Bligh &​ Dyer; Liquid Extraction:​ BUME; Liquid Extraction:​ Single-phase Butanol/​Methanol Extraction; Supercritical Fluid chromatography-mass spectrometry of lipids

Expansion of Targeted Hydrophobic Compounds Using a Modifier

As previously described, SC–CO2 is a suitable medium to extract hydrophobic compounds. On the other hand, complex lipids (e.g., phospholipids, PLs, and glycolipids, GLs) have higher polarity than neutral lipids (e.g., TAG), because they have a hydrophilic head groups (i.e., phosphate groups or sugars). Therefore, extraction efficiencies of complex lipids are lower than that of neutral lipids by SFE with SC–CO2. However, the polarity of SC–CO2 can be changed considerably by adding a polar organic solvent such as methanol, ethanol, etc., as a modifier. Thus, in recent years, many SFE applications using greener and less toxic ethanol ...

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