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Synaptic Remodeling and Neosynaptogenesis

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Book cover Handbook of the Cerebellum and Cerebellar Disorders

Abstract

This chapter describes axon-target interactions using the olivocerebellar path as a model, looking at the changes in synaptic contacts between climbing fibers and Purkinje cells in rodents, during developmental synapse formation, selective stabilization and synaptic re-formation during later stages of life. Neosynaptogenesis and recreation of the olivocerebellar circuit provides a model system for understanding how circuit reorganization after a lesion can be maximized for optimal repair. This model is used to examine how interactions between climbing fibers and Purkinje cells allow correct synaptic contacts to be established during development and post-lesion plasticity. This chapter also evaluates the relative importance of each synaptic partner, their maturation and prior synaptic experience, in determining the specificity of connections within a network. Developmental climbing fiber synapse formation and refinement is briefly described, then how the reformation of these contacts later in maturation is discussed, along with how these studies increase understanding of network development and stability.

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique, Université Pierre et Marie Curie–Paris6, Unité Mixte de Recherche 7102, 75005, Paris, France

    Dr. Ann M. Lohof, Dr. Mathieu Letellier, Dr. Jean Mariani & Prof. Rachel M. Sherrard

  2. Assistance Publique–Hôpitaux de Paris, Hôpital Charles Foix, Unité d’Exploration Fonctionnelles, 94200, Ivry–sur–Seine, France

    Dr. Jean Mariani

  3. MRC Laboratory for Molecular Cell Biology and Cell Biology Unit and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom

    Dr. Mathieu Letellier

Authors
  1. Dr. Ann M. Lohof
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  2. Dr. Mathieu Letellier
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  3. Dr. Jean Mariani
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  4. Prof. Rachel M. Sherrard
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Corresponding author

Correspondence to Ann M. Lohof .

Editor information

Editors and Affiliations

  1. Unité d'Etude du Mouvement (UEM), FNRS, Neurologie ULB Erasme, Bruxelles, Belgium

    Mario Manto

  2. Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  3. Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Orbassano, Turin, Italy

    Ferdinando Rossi

  4. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, California, CA, USA

    Donna L. Gruol

  5. Department of Integrative Physiolgy, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

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Lohof, A.M., Letellier, M., Mariani, J., Sherrard, R.M. (2013). Synaptic Remodeling and Neosynaptogenesis. In: Manto, M., Schmahmann, J.D., Rossi, F., Gruol, D.L., Koibuchi, N. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1333-8_13

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