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Geriatrische Onkologie pp 1–5Cite as

Kutanes Plattenepithelkarzinom beim alten und geriatrischen Patienten

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Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Das kutane Plattenepithelkarzinom ist der zweithäufigste maligne Tumor der Haut nach dem Basalzellkarzinom. Die chronische und kumulative UV-Exposition stellt den entscheidenden ätiologischen Faktor dar. Durch eine vollständige chirurgische Exzision sind ca. 95 % der kutanen Plattenepithelkarzinome kurabel und die Prognose ist somit in den meisten Fällen sehr gut. Bei einem geringen Anteil der Patienten tritt eine primär lymphogene Metastasierung ein, die mit einer schlechten Prognose verbunden ist. Mehrere patienten- und tumorspezifische Faktoren, die die Identifikation dieser Patienten ermöglichen, konnten ermittelt werden. In Fällen einer inoperablen Metastasierung sollte eine systemische Therapie möglichst im Rahmen einer klinischen Studie erfolgen, da derzeit keine ausreichend evidenzbelegte systemische Therapie zur Verfügung steht. Cisplatin und 5-Fluorouracil sowie Cetuximab stellen weitere Therapieoptionen dar.

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Authors and Affiliations

  1. Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland

    Miriam Linke & Azadeh Orouji

Authors
  1. Miriam Linke
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  2. Azadeh Orouji
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Corresponding author

Correspondence to Miriam Linke .

Editor information

Editors and Affiliations

  1. II. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany

    Matthias Ebert

  2. II. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany

    Nicolai Härtel

  3. Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Thüringen, Germany

    Ulrich Wedding

Section Editor information

  1. Interdisziplinäres Tumorzentrum, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland

    Nicolai Härtel

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Linke, M., Orouji, A. (2017). Kutanes Plattenepithelkarzinom beim alten und geriatrischen Patienten. In: Ebert, M., Härtel, N., Wedding, U. (eds) Geriatrische Onkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49083-9_41-1

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  • DOI: https://doi.org/10.1007/978-3-662-49083-9_41-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-49083-9

  • Online ISBN: 978-3-662-49083-9

  • eBook Packages: Springer Referenz Medizin

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