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Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss

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Textbook of Aging Skin

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Abstract

Human mesenchymal stem cells, by virtue of its capability to self-renew and differentiate into a variety of cell types, represent the first pluripotent stem cells to be used in clinical settings related to damage or degeneration. Therefore, there is an urgent need to understand how mesenchymal stem cells and their secretory factors contribute to regenerative medicine. Recent studies on the role of stem cells for skin and hair regeneration by many researchers including the authors have been remarkable. These scientific data enabled us to achieve the cost-effective treatment of skin aging using the legally acceptable cell therapeutic agents and their secretory factors. Objective data on the improvement of diverse aspects of skin aging including wound healing, wrinkle, and melasma due to photoaging have been available. Another progress has been made using the protein extract of the mesenchymal stem cells from the adipose tissue to promote hair growth in vitro, ex vivo, and in vivo by modulating the follicular cell cycles and hair cycle and protecting the follicular cells from androgens and reactive oxygen species. These approaches might mark the first practical application of stem cells among various trials in the field of skin and hair regeneration.

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Author information

Authors and Affiliations

  1. Cellpark Dermatology Clinic, Dosandaero 212, Gangnam-gu, 06047, Seoul, South Korea

    Byung-Soon Park

  2. Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, South Korea

    Won-Serk Kim

Authors
  1. Byung-Soon Park
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  2. Won-Serk Kim
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Corresponding author

Correspondence to Byung-Soon Park .

Editor information

Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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© 2017 Springer-Verlag Berlin Heidelberg

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Park, BS., Kim, WS. (2017). Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_20

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_20

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

  • eBook Packages: MedicineReference Module Medicine

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