Skip to main content
SpringerLink
Log in

Nierentransplantation: Chronische Transplantatschädigung

  • Living reference work entry
  • First Online:
SpringerReference Innere Medizin

Part of the book series: SpringerReference Medizin ((SRM))

  • 293 Accesses

Zusammenfassung

Die chronische Transplantatschädigung ist gekennzeichnet durch eine progrediente renale Narbenbildung, die sich klinisch im fortgeschrittenem Stadium durch eine Reduktion der Transplantatnierenfunktions sowie das Auftreten einer Proteinurie äußert. Ursächlich sind verschiedene immunologische und nichtimmunologische Schädigungsmechanismen. Die Therapie der chronischen Transplantatschädigung beruht auf der Behandlung dieser zugrunde liegenden Schädigungsmechanismen sowie der Kontrolle anderer renaler Risikofaktoren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Literatur

  • Cross NB, Webster AC, Masson P, O'Connell PJ, Craig JC (2009) Antihypertensives for kidney transplant recipients: systematic review and meta-analysis of randomized controlled trials. Transplantation 88:7–18

    Article  CAS  PubMed  Google Scholar 

  • Ekberg H, Tedesco-Silva H, Demirbas A et al (2007) Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 357:2562–2575

    Article  CAS  PubMed  Google Scholar 

  • Floege J, Johnson R, Feehally J (2010) Comprehensive Clinical Nephrology, 4. Aufl. Elsevier, Philadelphia, PA, USA, S 1200–1210

    Google Scholar 

  • Kee TY, Chapman JR, O'Connell PJ et al (2006) Treatment of subclinical rejection diagnosed by protocol biopsy of kidney transplants. Transplantation 82:36–42

    Article  CAS  PubMed  Google Scholar 

  • Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan B (2004) Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 4:378–383

    Article  PubMed  Google Scholar 

  • Naesens M, Kuypers DR, Sarwal M (2009) Calcineurin inhibitor nephrotoxicity. Clin J Am Soc Nephrol 4:481–508

    CAS  PubMed  Google Scholar 

  • Nankivell BJ, Fenton-Lee CA, Kuypers DR et al (2001a) Effect of histological damage on long-term kidney transplant outcome. Transplantation 71:515–523

    Article  CAS  PubMed  Google Scholar 

  • Nankivell BJ, Kuypers DR, Fenton-Lee CA et al (2001b) Histological injury and renal transplant outcome: the cumulative damage hypothesis. Transplant Proc 33:1149–1150

    Article  CAS  PubMed  Google Scholar 

  • Nankivell BJ, Borrows RJ, Fung CL et al (2003) The natural history of chronic allograft nephropathy. N Engl J Med 349:2326–2333

    Article  CAS  PubMed  Google Scholar 

  • Nankivell BJ, Wavamunno MD, Borrows RJ et al (2007) Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology. Am J Transplant 7:366–376

    Article  CAS  PubMed  Google Scholar 

  • Nickerson P, Jeffery J, Gough J et al (1998) Identification of clinical and histopathologic risk factors for diminished renal function 2 years posttransplant. J Am Soc Nephrol 9:482–487

    CAS  PubMed  Google Scholar 

  • Opelz G, Zeier M, Laux G, Morath C, Dohler B (2006) No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: a collaborative transplant study report. J Am Soc Nephrol 17:3257–3262

    Article  CAS  PubMed  Google Scholar 

  • Paul LC (1995) Chronic renal transplant loss. Kidney Int 47:1491–1499

    Article  CAS  PubMed  Google Scholar 

  • Seron D (2003) Protocol biopsies as predictors of chronic allograft nephropathy. Transplant Proc 35:2131–2132

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik fur Nieren- und Hochdruckkrankheiten, rheumatologische und immunologische, Universitatsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    Dr. med. Anja Mühlfeld

Authors
  1. Dr. med. Anja Mühlfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anja Mühlfeld .

Editor information

Editors and Affiliations

  1. Medizinische Klinik I, Universitätsklinikum Schleswig-Hoslstein, Campus Lübeck, Lübeck, Schleswig-Holstein, Germany

    Hendrik Lehnert

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Mühlfeld, A. (2014). Nierentransplantation: Chronische Transplantatschädigung. In: Lehnert, H. (eds) SpringerReference Innere Medizin. SpringerReference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54676-1_90-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54676-1_90-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-54676-1

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Search

Navigation