Abstract
The tremendous progress in the development of new technologies in the areas of molecular biology and bioinformatics enables interrogation of cellular responses to toxicant treatment at a global molecular level, allowing evaluation of toxic effects in the context of molecular pathways.
The major techniques currently employed, especially transcriptomics, but also proteomics and metabolomics, are being used and further evaluated in investigational toxicology. Since they already have been shown to provide increased insight into molecular mechanisms of toxicological effects, regulatory authorities are evaluating such data to prepare themselves for use in regulatory toxicology.
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© 2014 Springer-Verlag Berlin Heidelberg
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Ellinger-Ziegelbauer, H., Ahr, HJ. (2014). Omics in Toxicology. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35374-1_40
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DOI: https://doi.org/10.1007/978-3-642-35374-1_40
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-35373-4
Online ISBN: 978-3-642-35374-1
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