Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Immunotoxicology pp 1–3Cite as

Cardiac Disease, Autoimmune

  • Living reference work entry
  • First Online:

  • 179 Accesses

Synonyms

Autoimmune heart disease; Cardiomyopathy; Immune-mediated heart disease; Inflammatory heart disease; Myocarditis

Definition

A number of inflammatory diseases of the heart have been associated with autoimmune or other immune-mediated pathogenic mechanisms. The disease can affect any portion of the heart: the pericardium (surface of the heart), the myocardium (heart muscle), or the endocardium (lining and valves of the heart). Inflammation may occur in the coronary vessels that supply blood to the heart itself and lead to atherosclerosis. These inflammatory processes are often accompanied by autoimmune responses in the form of antibodies to antigens found in the heart. There are, however, very few instances where one can clearly state that these autoimmune responses are the cause rather than the result of heart disease in humans. On the other hand, there are a number of well-defined animal models of autoimmune heart disease. They can be cited as indirect evidence supporting an...

This is a preview of subscription content, log in via an institution.

References

  • Cihakova D and Rose NR. Pathogenesis of myocarditis and dilated cardiomyopathy. Adv Immunol 99:95–114, 2008.

    Article  PubMed  CAS  Google Scholar 

  • Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss H-P, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P and Elliott PM. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34:2636–2648, 2013.

    Article  PubMed  Google Scholar 

  • Rose NR and Kaya Z. (2014) Immune-mediated cardiovascular disease, Chapter 70. In: Rose NR, Mackay IR (eds) The autoimmune diseases, 5th edn. Elsevier/Academic, London, pp 875–888.

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Department of Molecular Microbiology and Immunology, Johns Hopkins University, 615 North Wolfe Street, 21205, Baltimore, USA

    Noel R. Rose

Authors
  1. Noel R. Rose
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Noel R. Rose .

Editor information

Editors and Affiliations

  1. Pharmaforschungszentrum, Bayer Health Care AG, Wuppertal, Nordrhein-Westfalen, Germany

    Hans-Werner Vohr

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Rose, N.R. (2014). Cardiac Disease, Autoimmune. In: Vohr, HW. (eds) Encyclopedia of Immunotoxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27786-3_209-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27786-3_209-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27786-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation